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Advanced filters: Author: Takuto Hideyama Clear advanced filters

  • The mislocalization and downregulation of the proteins TDP-43 and ADAR2, respectively, are implicated in amyotrophic lateral sclerosis pathology. Yamashita et al. find that downregulation of ADAR2 results in calcium-permeable AMPA receptor-mediated calpain activation and subsequent aberrant cleavage of TDP-43.

    • Takenari Yamashita
    • Takuto Hideyama
    • Shin Kwak
    Research
    Nature Communications
    Volume: 3, P: 1-13