Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–18 of 18 results
Advanced filters: Author: Tal Danino Clear advanced filters
  • In this Comment, Deb et al. explore ‘cancer art’ projects that enable new conversations for a broader audience, advocate for policy and disparity issues, and lead to creative innovations for research.

    • Dhruba Deb
    • Stefani Shoreibah
    • Tal Danino
    Comments & Opinion
    Nature Reviews Cancer
    Volume: 22, P: 191-192
  • CAPPSID relies on an engineered S. typhimurium to act as a synthetic ‘capsid’ to transcribe and deliver viral RNA inside cancer cells, launching a virus that can directly lyse surrounding cells.

    • Zakary S. Singer
    • Jonathan Pabón
    • Tal Danino
    ResearchOpen Access
    Nature Biomedical Engineering
    P: 1-11
  • The bacterium Proteus mirabilis natively forms a bullseye colony pattern by swarming. Doshi et al. engineered this bacterium to encode environmental inputs, including copper, into its pattern features, and decoded them with image processing and deep learning.

    • Anjali Doshi
    • Marian Shaw
    • Tal Danino
    Research
    Nature Chemical Biology
    Volume: 19, P: 878-886
  • A defining focus of synthetic biology is the engineering of genetic circuits with predictive functionality in living cells. Here, a decade after the first synthesized genetic toggle switch and oscillator, an engineered gene network with global intercellular coupling is designed that is capable of generating synchronized oscillations in a growing population of cells.

    • Tal Danino
    • Octavio Mondragón-Palomino
    • Jeff Hasty
    Research
    Nature
    Volume: 463, P: 326-330
  • Our ability to use engineered bacteria for cancer therapy is rapidly expanding. A survey of preclinical, clinical and commercial efforts provides an overview of the state of the field, revealing trends that could inform future directions.

    • Edward R. Ballister
    • Alexander Michels
    • Tal Danino
    Comments & Opinion
    Nature Biotechnology
    Volume: 43, P: 672-676
  • There is an unmet medical need for the detection and treatment of early adenomas to prevent their progression to malignant disease. Here the authors show that orally administered E. coli Nissle 1917 can selectively colonize adenomas in mouse models and in patients as a detection tool, as well as deliver immunotherapeutics for colorectal neoplasia treatment.

    • Candice R. Gurbatri
    • Georgette A. Radford
    • Tal Danino
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Bacteria spheroid coculture allows long-term growth of bacteria in the hypoxic, necrotic core of tumor spheroids. This enables the study of bacteria–tumor interactions and rapid development of engineered microbial therapies.

    • Tetsuhiro Harimoto
    • Dhruba Deb
    • Tal Danino
    Protocols
    Nature Protocols
    Volume: 17, P: 2216-2239
  • Probiotic Escherichia coli Nissle 1917 is engineered as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays to safely induce specific, effective and durable systemic antitumour immunity.

    • Andrew Redenti
    • Jongwon Im
    • Nicholas Arpaia
    ResearchOpen Access
    Nature
    Volume: 635, P: 453-461
  • Bacteria-based living drugs can treat a broad range of diseases. This Review discusses challenges to the clinical translation of engineered bacterial therapeutics and how advances in synthetic biology and nanomedicine can help overcome them.

    • Jaeseung Hahn
    • Suwan Ding
    • Tal Danino
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 120-135
  • Thousands of quorum-sensing Escherichia coli colonies are synchronized over centimetres using redox signalling to create ‘biopixels’ that can sense trace amounts of arsenic in water.

    • Arthur Prindle
    • Phillip Samayoa
    • Jeff Hasty
    Research
    Nature
    Volume: 481, P: 39-44
  • Clinically relevant bacteria have been engineered to lyse synchronously at a threshold population density and release genetically encoded therapeutics; treatment of mice with these bacteria slowed the growth of tumours.

    • M. Omar Din
    • Tal Danino
    • Jeff Hasty
    Research
    Nature
    Volume: 536, P: 81-85
  • Chimeric antigen receptor T cells (CAR-T cells) are often hindered by the concurrent challenges of variable antigen expression patterns and immunosuppressive tumor microenvironments. A new approach enhances CAR-T cells by coexpressing bacterial enzymes that activate prodrugs in high concentrations at the disease site.

    • Rosa Vincent
    • Tal Danino
    News & Views
    Nature Chemical Biology
    Volume: 18, P: 122-123
  • Flagellated bacteria coated with antigen-adsorbing nanoparticles and injected into irradiated tumours elicit systemic antitumour immune responses by transporting tumour antigens towards the tumour periphery, where they are taken up by functional antigen-presenting cells.

    • Andrew Redenti
    • Jaeseung Hahn
    • Tal Danino
    News & Views
    Nature Biomedical Engineering
    Volume: 6, P: 3-5