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Showing 1–5 of 5 results
Advanced filters: Author: Tamar Golan-Lev Clear advanced filters

  • Aberrant oncogene expression can cause replication stress leading to chromosomal breaks. Here the authors map the chromosomal break loci induced by two different oncogenes and by a replication inhibitor, and show that each treatment induces a unique pattern of breaks in the same cell type.

    • Karin Miron
    • Tamar Golan-Lev
    • Batsheva Kerem
    Research
    Nature Communications
    Volume: 6, P: 1-7

  • Trisomy 12 is the most frequent chromosomal abnormality detected in cultures of human pluripotent stem cells. Here the authors show that human pluripotent stem cells carrying this abnormality exhibit gene expression profiles more similar to those of germ cell tumours, and give rise to more aggressive teratomas.

    • Uri Ben-David
    • Gal Arad
    • Juan Carlos Biancotti
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Haploid human embryonic stem cells have been derived from haploid oocytes, the cells maintain a normal haploid karyotype as pluripotent cells and, unexpectedly, as differentiated cells — loss-of-function genetic screens previously performed with haploid embryonic stem cells in mice can now be performed in humans.

    • Ido Sagi
    • Gloryn Chia
    • Nissim Benvenisty
    Research
    Nature
    Volume: 532, P: 107-111