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Showing 1–7 of 7 results
Advanced filters: Author: Tamas Schauer Clear advanced filters

  • The molecular mechanisms underlying direct neuronal reprogramming are unclear. Here the authors show Ngn2-mediated chromatin remodeling and its binding sites underlying mouse astrocyte-to-neuron reprogramming and identify Yy1, a transcription co-factor, as an important regulator.

    • Allwyn Pereira
    • Jeisimhan Diwakar
    • Magdalena Götz
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 1260-1273

  • Genome-wide replication timing maps of mouse embryos from the zygote to the blastocyst stage were generated using single-cell Repli-seq, shedding light on the establishment of the epigenome at the beginning of mammalian development.

    • Tsunetoshi Nakatani
    • Tamas Schauer
    • Maria-Elena Torres-Padilla
    ResearchOpen Access
    Nature
    Volume: 625, P: 401-409

  • Nucleosomes form arrays with even spacing between them in virtually all eukaryotes; however, their biogenesis is incompletely understood. Here the authors show that nucleosome density and DNA sequence along with the Ino80 chromatin remodeling complex play a role in nucleosome array formation in yeast and that the transcriptional machinery disrupts evenly-spaced nucleosomes.

    • Ashish Kumar Singh
    • Tamás Schauer
    • Felix Mueller-Planitz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • The chromosomal kinase JIL-1 is responsible for interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from heterochromatinisation. Here, the authors show that JIL-1 is stabilized and anchored to active genes and telomeric transposons by JASPer, which binds to H3K36me3 nucleosomes via its PWWP domain.

    • Christian Albig
    • Chao Wang
    • Catherine Regnard
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The Braun lab shows that the conserved nuclear membrane protein Lem2 interacts with the MTREC complex of the nuclear-exosome pathway to promote recruitment and degradation of ncRNAs and meiotic transcripts at the nuclear periphery in Schizosaccharomyces pombe.

    • Lucía Martín Caballero
    • Matías Capella
    • Sigurd Braun
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 910-921

  • Spatial genome organization into lamina-associated domains is first established in the mouse zygote immediately after fertilization without inheritance from the maternal germline—with the paternal and maternal pronucleus exhibiting different organization, which subsequently converges prior to implantation of the embryo.

    • Máté Borsos
    • Sara M. Perricone
    • Jop Kind
    Research
    Nature
    Volume: 569, P: 729-733