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Showing 1–2 of 2 results
Advanced filters: Author: Tamayanthi Rajakumar Clear advanced filters

  • To prevent promiscuous protein degradation, proteasomes are initially assembled as inactive complexes. Their activation is autocatalytic and coupled to assembly. Here the authors uncover key aspects of the autocatalytic activation mechanism.

    • Benjamin Velez
    • Richard M. Walsh Jr.
    • John Hanna
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1167-1175

  • The proteasome core particle (CP) assembles through the fusion of two half-CP precursors, yielding a complete but immature CP structure. Here the authors identify by cryogenic electron microscopy the structure of a post-fusion assembly intermediate, revealing how associated factors collaborate to chaperone CP assembly and maturation.

    • Richard M. Walsh Jr.
    • Shaun Rawson
    • John Hanna
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1516-1524