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Showing 1–3 of 3 results
Advanced filters: Author: Tambudzai Shamu Clear advanced filters

  • How different oncogenic Akt mutants can affect the response to Akt inhibitors is currently unclear. Here, the authors analyse somatic mutations of Akt1-3 isoforms in several human cancers, investigate their oncogenic effects and therapeutic relevance in vitro and confirm some of their data in a clinical trial testing the AKT inhibitor capivasertib in patients with solid tumors harboring AKT alterations.

    • Tripti Shrestha Bhattarai
    • Tambudzai Shamu
    • Barry S. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Gastrointestinal stromal tumours (GIST) are believed to arise in interstitial cells of Cajal (ICC). These authors show that the transcription factor ETV1 is required for ICC development and promotes the development of GIST. KIT, which is often activated by mutations in GIST, cooperates with ETV1 in the transformation of ICCs, in part by promoting ETV1 stabilization. Thus, a normal developmental lineage factor is switched into a tumour-promoting factor by a cooperating oncogene.

    • Ping Chi
    • Yu Chen
    • Charles L. Sawyers
    Research
    Nature
    Volume: 467, P: 849-853