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Showing 1–4 of 4 results
Advanced filters: Author: Tan-Trung Nguyen Clear advanced filters

  • The authors uncover one of the largest mitoribosomes, dedicated to translating only three proteins in lethal human eukaryotic pathogens of the Apicomplexa phylum. All members of mitochondrial DNA-containing Myzozoa, including Toxoplasma gondii, have commandeered three lineage-specific families of RNA-binding proteins to meticulously piece together over 40 mitochondrial rRNA fragments to build an operational mitoribosome.

    • Chaoyue Wang
    • Sari Kassem
    • Yonggen Jia
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Cohesin functions must be tightly regulated. Here Prusén Mota et al. show that the cohesin regulator SORORIN is conserved beyond the animal kingdom and they provide the first organismal in vivo evidence that SORORIN antagonizes WAPL.

    • Ignacio Prusén Mota
    • Marta Galova
    • Peter Schlögelhofer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • This study characterized the unique protein subunit composition and structure of Arabidopsis mitochondrial ribosomes using biochemical assays and cryo-electron microscopy. Ten subunits are pentatricopeptide (PPR) proteins, among which rPPR1 functions as a translation factor.

    • Florent Waltz
    • Tan-Trung Nguyen
    • Philippe Giegé
    Research
    Nature Plants
    Volume: 5, P: 106-117