Nature Search

Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection

The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.

Chahat Mehra
Jesús Alvarado Valverde
Lena Pernas
ResearchOpen Access25 Nov 2025
Nature Microbiology

Volume: 10, P: 3331-3345
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Skeletal muscle derived Musclin protects the heart during pathological overload

Cachexia is associated with poor prognosis in heart failure. Here the authors show that mice and patients with cardiac cachexia display reduced skeletal muscle expression and circulating levels of Musclin. Musclin ablation in skeletal muscle worsens, while its muscle-specific overexpression ameliorates heart failure in mice.

Malgorzata Szaroszyk
Badder Kattih
Joerg Heineke
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-17
Serotonin receptor 3A controls interneuron migration into the neocortex

During brain development, neuronal excitability controls the laminar migration of cortical interneurons from the caudal ganglionic eminences (CGEs). Here the authors identify the 5-HT_3Areceptor as a specific marker of CGE-derived cortical interneurons (cINs), and as a stimulator of cIN migration.

Sahana Murthy
Mathieu Niquille
Alexandre Dayer
ResearchOpen Access20 Nov 2014
Nature Communications

Volume: 5, P: 1-10
Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

The oligodendrocyte lineage is known for its transcriptional heterogeneity, but the functional consequences of this are unclear. Here, the authors show that distinct populations of mature oligodendrocytes have spatial preferences in the brain and spinal cord and show different responses to spinal cord injury.

Elisa M. Floriddia
Tânia Lourenço
Gonçalo Castelo-Branco
ResearchOpen Access17 Nov 2020
Nature Communications

Volume: 11, P: 1-15
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures

Loss of canonical Notch signaling in vascular endothelial cells induces spontaneous formation of proto-typical tertiary lymphoid structures in mouse kidney, liver and lungs, which form around central arteries that acquire a high endothelial cell signature

Susanne Fleig
Tamar Kapanadze
Florian P. Limbourg
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-14
Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis

Birgit Obermeier
Reinhard Mentele
Klaus Dornmair
Research18 May 2008
Nature Medicine

Volume: 14, P: 688-693
∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-STAT and RhoA-ROCK pathways in an IL-6 dependent manner.

Hamish Campbell
Nicholas Fleming
Antony W. Braithwaite
ResearchOpen Access17 Jan 2018
Nature Communications

Volume: 9, P: 1-13
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease

Sarah Irmscher
Svante L. H. Zipfel
Christine Skerka
ResearchOpen Access18 Nov 2021
Scientific Reports

Volume: 11, P: 1-15
Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression

Marina Kazantseva
Noelyn A. Hung
Tania L. Slatter
ResearchOpen Access08 May 2017
Scientific Reports

Volume: 7, P: 1-7
Place-Based Education and Heritage Education in in-service teacher training: research on teaching practices in secondary schools in Galicia (NW Spain)

Tania Riveiro-Rodríguez
Andrés Domínguez-Almansa
Tomás Izquierdo Rus
ResearchOpen Access20 Jan 2021
Humanities and Social Sciences Communications

Volume: 8, P: 1-14
Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines

Sophie Chappuis-Flament
Andrea Pasini
Marc Billaud
Research07 Dec 1998
Oncogene

Volume: 17, P: 2851-2861
Rhythms of memory

Mitogen-activated Protein Kinases (MAPKs) are critical for the formation of stable long-term memories. New work shows that circadian MAPK activity cycling is important in the formation of new hippocampus-dependent memories.

Tania L Roth
J David Sweatt
News & Views01 Sept 2008
Nature Neuroscience

Volume: 11, P: 993-994
The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer

Marina Kazantseva
Sunali Mehta
Antony W. Braithwaite
ResearchOpen Access20 Aug 2019
Cell Death & Disease

Volume: 10, P: 1-17
Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment

Samantha M. Keller
Tiffany S. Doherty
Tania L. Roth
ResearchOpen Access16 Jul 2019
Scientific Reports

Volume: 9, P: 1-13
Abnormal Development of Monoaminergic Neurons Is Implicated in Mood Fluctuations and Bipolar Disorder

Marin M Jukic
Tania Carrillo-Roa
Claude Brodski
Research22 Sept 2014
Neuropsychopharmacology

Volume: 40, P: 839-848

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