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Showing 1–2 of 2 results
Advanced filters: Author: Tanja Musch Clear advanced filters

  • Hox gene expression is induced upon cellular differentiation and is inhibited in pluripotent cells. Bocker and colleagues show that the maintenance of induced transcription depends on Tet2 mediated hydroxylation of 5-methylcytosine at theHoxagene locus, indicating that this epigenetic switch is required for an active chromatin state and gene expression.

    • Michael T. Bocker
    • Francesca Tuorto
    • Achim Breiling
    Research
    Nature Communications
    Volume: 3, P: 1-12

  • Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis.

    • Francesca Tuorto
    • Reinhard Liebers
    • Frank Lyko
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 900-905