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Showing 1–2 of 2 results
Advanced filters: Author: Tanner S. Miest Clear advanced filters

  • Oncolytic viruses can infect and destroy tumour tissues; however, many have proven less effective in clinical trials than anticipated. Miest and Cattaneo outline strategies to enhance the efficacy of next-generation virotherapy and to provide the clinic with a range of viruses that are engineered to safely and specifically destroy cancer cells.

    • Tanner S. Miest
    • Roberto Cattaneo
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 23-34

  • Oncolytic viruses can be reprogrammed into vectors for use in cancer therapy by combining three types of modification: targeting, arming and shielding. Roberto Cattaneo and colleagues discuss the principles of virus reprogramming using adenovirus, a DNA virus with a naked icosahedral capsid, and measles virus, an enveloped RNA virus with a helical capsid, as the main examples.

    • Roberto Cattaneo
    • Tanner Miest
    • Michael A. Barry
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 529-540