Mutations in FOXF1, a key transcriptional regulator of pulmonary vascular development, cause Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins. Here, the authors discovered four genomic regions that control cell type-specific activity of Foxf1 during lung development and show that disrupting these regions via genetic deletions leads to alveolar capillary dysplasia.
- Guolun Wang
- Bingqiang Wen
- Vladimir V. Kalinichenko
