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Showing 1–2 of 2 results
Advanced filters: Author: Tarang Khare Clear advanced filters

  • The 5-hydroxymethylcytosine (5-hmC) nucleoside is abundant in the brain for unknown reasons. Genome-wide analysis of the distribution of 5-hmC versus 5-methylcytosine (5-mC) in human and mouse tissues now shows that 5-hmC is enriched in genes with synaptic functions. The differential distribution of 5-hmC versus 5-mC at exon-intron boundaries in both human and mouse tissues further suggests a possible role for 5-hmC in pre-mRNA splicing.

    • Tarang Khare
    • Shraddha Pai
    • Arturas Petronis
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1037-1043

  • Chemical modifications of CpG dinucleotides form part of the epigenetic code and various methods for the detection of modified CpG sites exist. Here Kriukiene and colleagues report a complementary method that allows the profiling of unmodified CpG sites within the genome, which they call the 'unmethylome'.

    • Edita Kriukienė
    • Viviane Labrie
    • Saulius Klimašauskas
    Research
    Nature Communications
    Volume: 4, P: 1-10