Nature Search

Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells

Zhuo Wang
Satoru Kyo
Masaki Inoue
Research21 May 2002
Oncogene

Volume: 21, P: 3517-3524
Dataset of Post-Event Survey of the 2024 Noto Peninsula Earthquake Tsunami in Japan

Masatoshi Yuhi
Shinya Umeda
Nobuhito Mori
ResearchOpen Access17 Jul 2024
Scientific Data

Volume: 11, P: 1-8
Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET

The innate antiviral immune response is an important defense against infection. Here, the authors show that leukocyte cell-derived chemotaxin 2 (LECT2) promotes RIG-I-mediated innate immune responses by preventing its degradation, and inhibits lymphocytic choriomeningitis virus replication in the liver.

Takayoshi Shirasaki
Satoshi Yamagoe
Masao Honda
ResearchOpen Access08 Jun 2022
Nature Communications

Volume: 13, P: 1-15
AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine

Efficient AAV gene delivery to the heart remains a challenge and hinders clinical translation. Here, coronary Stop-flow delivery with mechanical circulatory support dramatically improved gene expression while securing safety in a swine heart failure model.

Renata Mazurek
Serena Tharakan
Kiyotake Ishikawa
ResearchOpen Access01 Dec 2024
Nature Communications

Volume: 15, P: 1-12
Redefining the disease locus of 16q22.1-linked autosomal dominant cerebellar ataxia

Takeshi Amino
Kinya Ishikawa
Hidehiro Mizusawa
Research05 Jul 2007
Journal of Human Genetics

Volume: 52, P: 643-649
Serum laminin γ2 monomer as a predictive biomarker for hepatocellular carcinoma in patients with chronic hepatitis B virus infection: a retrospective cohort study

Kouki Nio
Tetsuro Shimakami
Taro Yamashita
ResearchOpen Access25 Oct 2024
Scientific Reports

Volume: 14, P: 1-6
Peptide vaccine-treated, long-term surviving cancer patients harbor self-renewing tumor-specific CD8⁺ T cells

The success of peptide vaccine treatment in cancer relies on the build-up of an efficient cytotoxic T cell response against the tumour antigen. Authors show here that tumour-specific memory CD8 T cells are able to persist and possibly even proliferate in the peripheral blood of long-surviving hepatocellular carcinoma patients.

Eishiro Mizukoshi
Hidetoshi Nakagawa
Shuichi Kaneko
ResearchOpen Access03 Jun 2022
Nature Communications

Volume: 13, P: 1-11
Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry

Hisashi Fukuyama
Hiroto Ishikawa
Shin Yamane
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model

Ikufumi Takahashi
Keisuke Takeda
Masahiro Hoso
ResearchOpen Access08 May 2024
Scientific Reports

Volume: 14, P: 1-10
Tailoring extreme-ultraviolet light

The emission direction and timing of extreme-ultraviolet light can now be manipulated through an opto-optical approach that uses an infrared pulse to control the spatial and spectral phase of free induction decay resulting from atoms excited by attosecond light.

Taro Sekikawa
Kenichi L. Ishikawa
News & Views04 Apr 2017
Nature Photonics

Volume: 11, P: 209-210
High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons

The first intracellular recordings from presynaptic boutons in the intact mammalian brain are presented. These results contradict the prevailing views (derived from in vitro work) on how the cerebellum integrates sensory information to control movement, by revealing a hitherto unexpected sensitivity of single brain connections to stimuli from the environment.

Ede A. Rancz
Taro Ishikawa
Michael Häusser
Research20 Dec 2007
Nature

Volume: 450, P: 1245-1248
Targeted delivery of therapeutic agents to the heart

For therapeutic materials to be delivered to the heart, several barriers need to be overcome. In this Review, Ishikawa and colleagues discuss strategies for targeted delivery of therapeutic materials to the heart, including the use of adeno-associated viruses and exosomes, with a focus on agents directed at modifying gene expression.

Susmita Sahoo
Taro Kariya
Kiyotake Ishikawa
Reviews26 Jan 2021
Nature Reviews Cardiology

Volume: 18, P: 389-399
Electroconvulsive therapy-specific volume changes in nuclei of the amygdala and their relationship to long-term anxiety improvement in depression

Yuzuki Ishikawa
Naoya Oishi
Taro Suwa
ResearchOpen Access16 Dec 2024
Molecular Psychiatry

Volume: 30, P: 2653-2664
Dendritic excitation–inhibition balance shapes cerebellar output during motor behaviour

Here, the authors combinein vivopatch-clamp recordings and optogenetics to show that balanced dendritic excitation and inhibition provides a sensitive ‘push-pull’ mechanism that generates the bidirectional modulation of Purkinje cell SSp output necessary for normal locomotor behaviour.

Marta Jelitai
Paolo Puggioni
Ian Duguid
ResearchOpen Access15 Dec 2016
Nature Communications

Volume: 7, P: 1-13
Violet bioluminescent Polycirrus sp. (Annelida: Terebelliformia) discovered in the shallow coastal waters of the Noto Peninsula in Japan

Shusei Kanie
Daisuke Miura
Yasuo Mitani
ResearchOpen Access27 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition

Takuya Ishikawa
Yasuyuki Kitaura
Yoshiharu Shimomura
ResearchOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Long-term outcomes after endoscopic retrograde pancreatic drainage for symptomatic pancreaticojejunal anastomotic stenosis

Akihiko Kida
Yukihiro Shirota
Tokio Wakabayashi
ResearchOpen Access24 Feb 2021
Scientific Reports

Volume: 11, P: 1-8
Transcription factor JUNB is required for transformation of EpCAM-positive hepatocellular carcinoma (HCC) cells into CD90-positive HCC cells in vitro

Yutaro Kawakami
Hikari Okada
Taro Yamashita
ResearchOpen Access19 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-14
Direct and accurate measurement of CAG repeat configuration in the ataxin-1 (ATXN-1) gene by “dual-fluorescence labeled PCR-restriction fragment length analysis”

Jiang X. Lin
Kinya Ishikawa
Hidehiro Mizusawa
Research01 Apr 2008
Journal of Human Genetics

Volume: 53, P: 287-295
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein – Barr virus

Hidetoshi Tahara
Yoshiki Tokutake
Masanobu Sugimoto
Research16 Oct 1997
Oncogene

Volume: 15, P: 1911-1920
Mint3-depletion-induced energy stress sensitizes triple-negative breast cancer to chemotherapy via HSF1 inactivation

Noritaka Tanaka
Hikari Okada
Takeharu Sakamoto
ResearchOpen Access11 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-12
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

Masaya Funaki
Juria Kitabayashi
Shuichi Kaneko
ResearchOpen Access05 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

Shutaro Shibata
Moeko Noguchi-Shinohara
Yutaka Kiyohara
ResearchOpen Access07 Jan 2025
npj Science of Food

Volume: 9, P: 1-8
Allosteric regulation by cooperative conformational changes of actin filaments drives mutually exclusive binding with cofilin and myosin

Kien Xuan Ngo
Nobuhisa Umeki
Taro Q. P. Uyeda
ResearchOpen Access20 Oct 2016
Scientific Reports

Volume: 6, P: 1-11
HIF-1-mediated activation of telomerase in cervical cancer cells

Noriyuki Yatabe
Satoru Kyo
Masaki Inoue
Research29 Mar 2004
Oncogene

Volume: 23, P: 3708-3715
hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin

Mitsuhiro Nakamura
Satoru Kyo
Naofumi Mukaida
Research18 Dec 2003
Cancer Gene Therapy

Volume: 11, P: 1-7
Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway

Yoshiko Maida
Satoru Kyo
Masaki Inoue
Research05 Jun 2002
Oncogene

Volume: 21, P: 4071-4079
Simultaneous silence organizes structured higher-order interactions in neural populations

Hideaki Shimazaki
Kolia Sadeghi
Taro Toyoizumi
ResearchOpen Access28 Apr 2015
Scientific Reports

Volume: 5, P: 1-13
Efficacy of a novel self-expandable metal stent with dumbbell-shaped flare ends for distal biliary obstruction due to unresectable pancreatic cancer

Masaki Miyazawa
Hajime Takatori
Shuichi Kaneko
ResearchOpen Access06 Dec 2022
Scientific Reports

Volume: 12, P: 1-9
Association between human papillomavirus particle production and the severity of recurrent respiratory papillomatosis

Satoshi Yamada
Toshiya Itoh
Hideya Kawasaki
ResearchOpen Access06 Apr 2023
Scientific Reports

Volume: 13, P: 1-13
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Erratum: Simultaneous silence organizes structured higher-order interactions in neural populations

Hideaki Shimazaki
Kolia Sadeghi
Taro Toyoizumi
Amendments and CorrectionsOpen Access09 Oct 2015
Scientific Reports

Volume: 5, P: 1-2
A novel α-fetoprotein-derived helper T-lymphocyte epitope with strong immunogenicity in patients with hepatocellular carcinoma

Toshikatsu Tamai
Eishiro Mizukoshi
Shuichi Kaneko
ResearchOpen Access04 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice

Misa Shimuta et al. evaluate the responses of cerebellar granule and Purkinje cells to tactile lip stimulation accompanied by optogenetic silencing of the rodent primary somatosensory cortex (S1). They show that peripheral sensory information converges with S1 signals onto the same granule cell, and that this integration affects the output of both granule and Purkinje cells.

Misa Shimuta
Izumi Sugihara
Taro Ishikawa
ResearchOpen Access15 Jul 2020
Communications Biology

Volume: 3, P: 1-12
Frequency of FGF14 intronic GAA repeat expansion in patients with multiple system atrophy and undiagnosed ataxia in the Japanese population

Toshiyuki Kakumoto
Kenta Orimo
Shoji Tsuji
ResearchOpen Access27 Nov 2024
European Journal of Human Genetics

Volume: 33, P: 325-333
Hypothermic temperature effects on organ survival and restoration

Jun Ishikawa
Masamitsu Oshima
Takashi Tsuji
ResearchOpen Access22 Apr 2015
Scientific Reports

Volume: 5, P: 1-12
Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the expression of CD90

Mariko Yoshida
Taro Yamashita
Shuichi Kaneko
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells

Noriyuki Yatabe
Satoru Kyo
Masaki Inoue
Research14 Jun 2002
Cancer Gene Therapy

Volume: 9, P: 624-630
Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers

Taro Kanaya
Satoru Kyo
Masaki Inoue
Research17 Apr 2003
Oncogene

Volume: 22, P: 2352-2360
Establishment and Characterization of a New Cell Line Permissive for Hepatitis C Virus Infection

Hitoshi Omura
Fanwei Liu
Shuichi Kaneko
ResearchOpen Access28 May 2019
Scientific Reports

Volume: 9, P: 1-14
Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

Taito Miyake
Norihiko Sakai
Takashi Wada
ResearchOpen Access31 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
A Novel Localized Amyloidosis Associated with Lactoferrin in the Cornea

Yukio Ando
Masaaki Nakamura
Makoto Uchino
Research01 Jun 2002
Laboratory Investigation

Volume: 82, P: 757-766
Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis for non-surgical treatment of moderate to severe periodontitis: a randomized controlled trial

Taro Kanno
Keisuke Nakamura
Keiichi Sasaki
ResearchOpen Access25 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
AAV shedding after intracoronary delivery: just a safety concern?

Kelly P. Yamada
Taro Kariya
Kiyotake Ishikawa
Comments & Opinion03 Dec 2019
Gene Therapy

Volume: 27, P: 111-112
Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan

Kennosuke Tsuda
Takeo Mukai
Kayo Yoshikawa
ResearchOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Effect of surgeon-related factors on outcome of retinal detachment surgery: analyses of data in Japan-retinal detachment registry

Keita Yamakiri
Taiji Sakamoto
Shin Yamane
ResearchOpen Access10 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Citizen science via social media revealed conditions of symbiosis between a marine gastropod and an epibiotic alga

Osamu Kagawa
Shota Uchida
Ryoya Sugimoto
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Regional and sex differences in retinal detachment surgery: Japan-retinal detachment registry report

Ryoh Funatsu
Hiroto Terasaki
Shin Yamane
ResearchOpen Access18 Oct 2021
Scientific Reports

Volume: 11, P: 1-9

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