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Showing 1–2 of 2 results
Advanced filters: Author: Tarsem Moudgil Clear advanced filters

  • Effective strategies to enhance T cell anti-tumor cytotoxicity are pivotal to improve treatment outcomes. By analyzing tumor samples from patients with head and neck or colon cancers, here the authors show that IL-12 can induce the expression of the inhibitory receptor NKG2A on tumor-reactive CD8 cytotoxic lymphocytes.

    • Olivier Fesneau
    • Kimberly A. Samson
    • Thomas Duhen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Identifying and enumerating tumor-specific CD8 T cells are important for assessing cancer prognosis and therapy efficacy. Here the authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit characteristics of exhausted or tissue-resident memory T cells.

    • Thomas Duhen
    • Rebekka Duhen
    • Andrew D. Weinberg
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13