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Showing 1–3 of 3 results
Advanced filters: Author: Tassja J. Spindler Clear advanced filters

  • Genome-wide association studies have identified regions which confer risk of high-grade serous epithelial ovarian cancer. Here the authors use expression quantitative train locus analysis to identify candidate genes and functionally characterise them, identifying a role for HOXD9 in ovarian cancer.

    • Kate Lawrenson
    • Qiyuan Li
    • Matthew L. Freedman
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-14

  • Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian cancer (EOC). They also test variants at the 12 known and 6 new EOC susceptibility loci for association in BRCA1 and BRCA2 mutation carriers.

    • Karoline B Kuchenbaecker
    • Susan J Ramus
    • Georgia Chenevix-Trench
    Research
    Nature Genetics
    Volume: 47, P: 164-171

  • Simon Gayther and colleagues report 3 new risk variants for mucinous ovarian carcinoma (MOC) on the basis of an analysis of 1,644 MOC cases and 21,693 controls. They confirm an eQTL association between the HOXD9 promoter and risk SNPs at 2q31.1 using chromosome conformation capture analysis and show that HOXD9 overexpression associates with neoplastic transformation.

    • Linda E Kelemen
    • Kate Lawrenson
    • Andrew Berchuck
    Research
    Nature Genetics
    Volume: 47, P: 888-897