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Showing 1–4 of 4 results
Advanced filters: Author: Taylor Sicard Clear advanced filters

  • The B-cell-specific co-receptor CD22 is a therapeutic target for depleting dysregulated B cells. Here the authors structurally characterize the ectodomain of CD22 and present its crystal structure with the bound therapeutic antibody epratuzumab, which gives insights into the mechanism of inhibition of B-cell activation.

    • June Ereño-Orbea
    • Taylor Sicard
    • Jean-Philippe Julien
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Here, the authors combine three different antibody specificities and an Fc domain on a single multivalent molecule, resulting in high neutralization activity despite viral sequence variability.

    • Edurne Rujas
    • Iga Kucharska
    • Jean-Philippe Julien
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, binding its ligand (ICOS-L) on activated T cells. The structure of the ICOS/ICOS-L complex reveals a distinct receptor binding orientation. The structures of ICOS and ICOS-L in complex with potentially therapeutic antibodies suggest the structural basis of such antibodies’ efficacies and high binding affinities.

    • Edurne Rujas
    • Hong Cui
    • Jean-Philippe Julien
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The Membrane-Proximal External Region (MPER) of the HIV Env gp41 subunit is a target for broadly neutralizing antibodies. Here, the authors apply super-resolution stimulated emission depletion (STED) microscopy on single virions and provide insights into how the MPER epitope is recognized.

    • Pablo Carravilla
    • Jakub Chojnacki
    • José L. Nieva
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11