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Showing 1–3 of 3 results
Advanced filters: Author: Terrell Holloway Clear advanced filters

  • The authors show that chronic treatment with antipsychotic drugs decreases expression of mGlu2 and histone acetylation at its promoter in frontal cortex. This is mediated through 5-HT2A receptor–dependent upregulation of HDAC2. HDAC inhibitors prevent this decrease in mGluR2, augmenting the behavioral effects of antipsychotics.

    • Mitsumasa Kurita
    • Terrell Holloway
    • Javier González-Maeso
    Research
    Nature Neuroscience
    Volume: 15, P: 1245-1254

  • Antipsychotic treatment in patients with schizophrenia often reduces hallucinations and delusions, but cognitive deficits that impair performance of everyday activities may persist or worsen. Our findings reveal a mechanism by which increased NF-κB activity leads to increased HDAC2 levels, impairing synaptic plasticity and memory during prolonged antipsychotic treatment.

    • Daisuke Ibi
    • Mario de la Fuente Revenga
    • Javier González-Maeso
    Research
    Nature Neuroscience
    Volume: 20, P: 1247-1259