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Scientific Reports (3)
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Showing 1–7 of 7 results

Advanced filters: Author: Tetsuro Yoshimaru Clear advanced filters

Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells

Oestrogen receptor-α (ERα) signalling has a role in breast cancer drug resistance. Here, the authors report a synthetic peptide that disrupts the interaction between the signalling molecules BIG3 and PHB2, and thereby suppresses tamoxifen resistance.

Tetsuro Yoshimaru
Masato Komatsu
Toyomasa Katagiri
ResearchOpen Access20 Sept 2013
Nature Communications

Volume: 4, P: 1-13
A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells

BIG3 is highly expressed in breast cancers and its interaction with PHB2 results in constitutive activation of E2/ERa signalling. Here the authors unveil the mechanistic details of this regulation showing that BIG3 binds PKA and regulates PP1Ca activity in an oestrogen-dependent manner.

Tetsuro Yoshimaru
Masaya Ono
Toyomasa Katagiri
ResearchOpen Access30 May 2017
Nature Communications

Volume: 8, P: 1-12
Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019

Masahito Nakano
Hiroshi Yatsuhashi
Takuji Torimura
ResearchOpen Access27 Jan 2022
Scientific Reports

Volume: 12, P: 1-6
Effect of Acute and Long-Term Aerobic Exercise on Arterial Stiffness in the Elderly

Yasuharu Tabara
Toshiaki Yuasa
Katsuhiko Kohara
Research01 Oct 2007
Hypertension Research

Volume: 30, P: 895-902
Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Tetsuro Yoshimaru
Keisuke Aihara
Toyomasa Katagiri
ResearchOpen Access12 May 2017
Scientific Reports

Volume: 7, P: 1-11
Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions

Tetsuro Yoshimaru
Masato Komatsu
Toyomasa Katagiri
ResearchOpen Access08 Dec 2014
Scientific Reports

Volume: 4, P: 1-9
Functional genomics for breast cancer drug target discovery

Tetsuro Yoshimaru
Yusuke Nakamura
Toyomasa Katagiri
ReviewsOpen Access20 Jul 2021
Journal of Human Genetics

Volume: 66, P: 927-935