The Notch pathway has been shown to act in both an oncogenic and a tumour-suppressive manner depending on its cellular context, and blocking or restoring the Notch pathway could offer a novel therapeutic target in patients with bladder cancer. In this Review, the authors describe what is known about Notch in cancer and discuss the role and potential of this signalling pathway in bladder cancer.
- Akihiro Goriki
- Roland Seiler
- Peter C. Black