PGC-1 family transcription factors are important regulators of cellular energy metabolism. Here the authors use tissue-specific, inducible PGC-1β KO mice to show that PGC-1 family members are not functionally redundant and that PGC-1β is required to maintain mitochondrial function in skeletal muscle.
- Thanuja Gali Ramamoorthy
- Gilles Laverny
- Daniel Metzger