Evidence is increasing that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Here, van den Broek et al. provide a revised view of the naive T cell compartment and then discuss the implications for ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.
- Theo van den Broek
- José A. M. Borghans
- Femke van Wijk