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Showing 1–5 of 5 results
Advanced filters: Author: Thomas A. Shaler Clear advanced filters
  • Mass spectrometry is used to systematically analyse the brains of patients suffering from Huntingdon's disease, as well as several mouse models of the disease, for the presence of ubiquitin chains. In all cases, an accumulation of ubiquitin chains was found, suggesting that a general dysfunction of this system may contribute to the disease process.

    • Eric J. Bennett
    • Thomas A. Shaler
    • Ron R. Kopito
    Research
    Nature
    Volume: 448, P: 704-708
  • Ubiquitin, an important post-translational modification that regulates a variety of biological processes is found in free and conjugated (monoubiquitin and polyubiquitin) forms in the cell. A method for precisely measuring these cellular pools using protein standard absolute quantification mass spectrometry is described; the approach should yield insights into ubiquitin signaling.

    • Stephen E Kaiser
    • Brigit E Riley
    • Ron R Kopito
    Research
    Nature Methods
    Volume: 8, P: 691-696
  • Improperly folded proteins are targeted for destruction through the endoplasmic-reticulum-associated degradation pathway (ERAD). Kopito and colleagues present a high-resolution interaction analysis of the ERAD system in combination with functional genomics, and identify new ERAD components.

    • John C. Christianson
    • James A. Olzmann
    • Ron R. Kopito
    Research
    Nature Cell Biology
    Volume: 14, P: 93-105