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Showing 1–9 of 9 results
Advanced filters: Author: Thomas E. Gorochowski Clear advanced filters

  • In this CRISPR-based feedback control system, sgRNA expression is triggered by the burden of protein overexpression, and the sgRNA directs repression of the exogenous gene promoter to reduce burdensome expression and restore growth of the cell.

    • Francesca Ceroni
    • Alice Boo
    • Tom Ellis
    Research
    Nature Methods
    Volume: 15, P: 387-393

  • A massive study informed by Design of Experiments uncovers factors that boost protein synthesis.

    • Thomas E Gorochowski
    • Tom Ellis
    News & Views
    Nature Biotechnology
    Volume: 36, P: 934-935

  • Inducible gene expression systems should minimise leaky output and offer a large achievable range of expression. Here, the authors regulate transcription and translation together to suppress noise and create digital-like responses, while maintaining a large expression range in vivo and in vitro.

    • F. Veronica Greco
    • Amir Pandi
    • Thomas E. Gorochowski
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Transcriptional terminators are generally viewed as hard endpoints for transcribing RNA polymerases. Here, the authors reimagine terminators as transcriptional valves with predictable read through. They engineer and characterize 1780 valves and use them for multiplexed gene regulation.

    • Matthew J. Tarnowski
    • Thomas E. Gorochowski
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Synthetic genetic circuits are sensitive to their environment and host cell, requiring many rounds of physical reassembly to achieve a desired function. Here the authors use a multi-level regulatory motif to dynamically tune the function of genetic parts as a step towards robust adaptive circuits.

    • Vittorio Bartoli
    • Grace A. Meaker
    • Thomas E. Gorochowski
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Ant and honeybee workers specialize on certain tasks and also on zones within the nest; but how do they avoid straying into the wrong zone? The authors conduct automated tracking experiments following thousands of individuals, revealing that workers use context-dependent rules to navigate inside the nest.

    • Thomas O. Richardson
    • Nathalie Stroeymeyt
    • Laurent Keller
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Evolutionary and rational design approaches are commonly used to engineer biological systems but are typically seen at odds with each other. In this perspective the authors argue for the concept of an evolutionary design spectrum to help unify and compare these design methodologies to support more effective biological engineering.

    • Simeon D. Castle
    • Michiel Stock
    • Thomas E. Gorochowski
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Effective biological engineering requires the acknowledgement of evolution and its consideration during the design process. In this perspective, the authors present the concept of the evotype to reason about and shape the evolutionary potential of natural and engineered biosystems.

    • Simeon D. Castle
    • Claire S. Grierson
    • Thomas E. Gorochowski
    ReviewsOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Synthetic biology uses cells as its computing substrate, often based on the genetic circuit concept. In this Perspective, the authors argue that existing synthetic biology approaches based on classical models of computation limit the potential of biocomputing, and propose that living organisms have under-exploited capabilities.

    • Lewis Grozinger
    • Martyn Amos
    • Angel Goñi-Moreno
    ReviewsOpen Access
    Nature Communications
    Volume: 10, P: 1-11