Nature Search

Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease

Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal disorders and common complex skeletal diseases.

Scott E. Youlten
John P. Kemp
Peter I. Croucher
ResearchOpen Access05 May 2021
Nature Communications

Volume: 12, P: 1-21
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Thomas G. Graeber
Cynthia Osmanian
Amato J. Giaccia
Research04 Jan 1996
Nature

Volume: 379, P: 88-91
Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance

Claire M. Storey
Mohamed Altai
David Ulmert
ResearchOpen Access30 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-17
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Cancer cells have been shown to be dependent upon glutamine for growth. Here, the authors show that intracellular asparagine, a glutamine-derived metabolite, is critical to cancer cell growth and can compensate glutamine deficiency by acting as an amino acid exchange factor.

Abigail S. Krall
Shili Xu
Heather R. Christofk
ResearchOpen Access29 Apr 2016
Nature Communications

Volume: 7, P: 1-13
Consistent stoichiometric long-term relationships between nutrients and chlorophyll-a across shallow lakes

Nutrient limitation is a well-known control of phytoplankton growth, but predicting specific responses in individual lakes based on nutrient data alone has proven challenging. Here, the authors show that long-term signals of chlorophyll-a dynamics in shallow lakes can be captured based on stoichiometric effects of N and P concentrations along a continuum of total N:total P ratios.

Daniel Graeber
Mark J. McCarthy
Thomas A. Davidson
ResearchOpen Access27 Jan 2024
Nature Communications

Volume: 15, P: 1-9
Leidenfrost droplet trampolining

The classic Leidenfrost phenomenon is familiar, yet its physics is rather complex. Graeber et al. observe the unexpected development of repeated hopping of a droplet trampolining on its own vapor cushion on a hot plate and show under which conditions this self-initiated motion occurs.

Gustav Graeber
Kartik Regulagadda
Dimos Poulikakos
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-7
Carbon and sulphur isotopic composition of Kilauea parental magma

Terrence M. Gerlach
Donald M. Thomas
Research06 Feb 1986
Nature

Volume: 319, P: 480-483
Bimodality and alternative equilibria do not help explain long-term patterns in shallow lake chlorophyll-a

Shallow lakes have long been considered an example of alternative equilibria in ecological systems. Here, the authors combine empirical data and simulations to show that the relationship of shallow lake chlorophyll-a with nutrient enrichment does not fit the theory of alternative stable states.

Thomas A. Davidson
Carl D. Sayer
Daniel Graeber
ResearchOpen Access25 Jan 2023
Nature Communications

Volume: 14, P: 1-11
Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo

L Webster
RJ Hodgkiss
GD Wilson
Research01 Jan 1998
British Journal of Cancer

Volume: 77, P: 227-234
Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma

Genomic profiling of tumours can help tailer treatments to the patient, however, it often fails to accurately predict therapeutic outcomes. Here, the authors combine molecular and functional characterisation via BH3 profiling to identify therapeutically targetable vulnerabilities in glioma.

Elizabeth G. Fernandez
Wilson X. Mai
David A. Nathanson
ResearchOpen Access21 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Correction: Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

Zhengshan Chen
Seyedmehdi Shojaee
Markus Müschen
Amendments and Corrections09 Mar 2016
Nature

Volume: 534, P: 138
NOD2 triggers an interleukin-32–dependent human dendritic cell program in leprosy

In human leprosy, a dendritic cell differentiation pathway that depends on interleukin-32 and is induced by NOD2 represents a novel mechanism of host defense against infection.

Mirjam Schenk
Stephan R Krutzik
Robert L Modlin
Research25 Mar 2012
Nature Medicine

Volume: 18, P: 555-563
Defining the ATPome reveals cross-optimization of metabolic pathways

Energy metabolism and ATP levels are controlled by an interlocking network of pathways. Here, the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define the “ATPome”, a map of pathways that contribute to cellular ATP regulation.

Neal K. Bennett
Mai K. Nguyen
Ken Nakamura
ResearchOpen Access28 Aug 2020
Nature Communications

Volume: 11, P: 1-16
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Although clinical trials have shown that RAF inhibitors prolong the survival of patients with BRAF-mutant melanoma, resistance inevitably develops; resistance is shown here to be frequently mediated by the expression of splicing variants of mutant BRAF.

Poulikos I. Poulikakos
Yogindra Persaud
David B. Solit
Research23 Nov 2011
Nature

Volume: 480, P: 387-390
Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles

Thomas G. Graeber
David Eisenberg
Research29 Oct 2001
Nature Genetics

Volume: 29, P: 295-300
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells

Stephan R Krutzik
Belinda Tan
Robert L Modlin
Research08 May 2005
Nature Medicine

Volume: 11, P: 653-660
MicroRNA-21 targets the vitamin D–dependent antimicrobial pathway in leprosy

The ability of Mycobacterium leprae to upregulate miRNA-21 provides an effective mechanism for the pathogen to escape from the vitamin D–dependent antimicrobial pathway.

Philip T Liu
Matthew Wheelwright
Robert L Modlin
Research29 Jan 2012
Nature Medicine

Volume: 18, P: 267-273
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

As opposed to its tumor suppressor role in other cancers, PTEN inhibition in pre-B ALL is therapeutically effective and triggers cell death.

Seyedmehdi Shojaee
Lai N Chan
Markus Müschen
Research14 Mar 2016
Nature Medicine

Volume: 22, P: 379-387
Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors

Lai N. Chan
Zhengshan Chen
Markus Müschen
Amendments and Corrections30 May 2018
Nature

Volume: 558, P: E5
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication

Viruses can reprogram glutamine metabolism of host cells to support bioenergetics demands of viral replication. Here the authors show that adenoviral infection leads to enhanced glutamine metabolism through virus-mediated activation of MYC, which is required for optimal progeny virion generation.

Minh Thai
Shivani K. Thaker
Heather R. Christofk
ResearchOpen Access12 Nov 2015
Nature Communications

Volume: 6, P: 1-9
826 ACYCLOVIR: THERAPY OF V-Z INFECTIONS IN CHILDREN WITH MALIGNANCIES

Thomas R Kinney
Laura T Gutman
John M Falletta
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 580
Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults

Jeeyeon Kim
Miesha Farahmand
Jeffrey J. Wine
ResearchOpen Access02 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

Increased expression of MITF transcription factor is thought to promote melanoma progression and kinase inhibitor resistance. Here Muller et al. show that MITF loss is also common in melanomas and confers kinase inhibitor resistance due to upregulation of AXL and other receptor tyrosine kinases.

Judith Müller
Oscar Krijgsman
Daniel S. Peeper
Research15 Dec 2014
Nature Communications

Volume: 5, P: 1-15
Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

The Inflammatory Bowel Disease Multi’omics Database includes longitudinal data encompassing a multitude of analyses of stool, blood and biopsies of more than 100 individuals, and provides a comprehensive description of host and microbial activities in inflammatory bowel diseases.

Jason Lloyd-Price
Cesar Arze
Curtis Huttenhower
ResearchOpen Access29 May 2019
Nature

Volume: 569, P: 655-662
Freezing-induced wetting transitions on superhydrophobic surfaces

Icephobic surfaces are helpful for increasing safety and sustainability in engineering applications. A study of the behaviour of supercooled droplets freezing on superhydrophobic surfaces now provides insights into ice-repellency mechanisms.

Henry Lambley
Gustav Graeber
Dimos Poulikakos
ResearchOpen Access09 Feb 2023
Nature Physics

Volume: 19, P: 649-655
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

During B cell development, cells that fail to productively rearrange their immunoglobulin VH-DJH gene segments to generate an in-frame junction that codes for a functional pre-B cell receptor are deleted. Markus Müschen and colleagues now report that Bach2 is a key component of this pre-B cell receptor checkpoint that enables the elimination of normal and transformed B cells with nonfunctional V(D)J rearrangements by regulating the expression of p53.

Srividya Swaminathan
Chuanxin Huang
Markus Müschen
Research14 Jul 2013
Nature Medicine

Volume: 19, P: 1014-1022
Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

T cell division is an intense metabolic process, and meeting its demands requires extensive metabolic reprogramming of the cell. Bensinger and colleagues demonstrate that SREBPs are critical for this reprogramming.

Yoko Kidani
Heidi Elsaesser
Steven J Bensinger
Research07 Apr 2013
Nature Immunology

Volume: 14, P: 489-499
Lactate dehydrogenase activity drives hair follicle stem cell activation

Flores et al. show that hair follicle stem cells rely on the production of lactate via the LDHA enzyme to become activated. Inducing Ldha through Mpc1 inhibition or Myc activation successfully reactivates the hair cycle in quiescent follicles.

Aimee Flores
John Schell
William E. Lowry
Research14 Aug 2017
Nature Cell Biology

Volume: 19, P: 1017-1026
Spontaneous droplet trampolining on rigid superhydrophobic surfaces

Spontaneous levitation and trampoline-like bouncing behaviour of water droplets on rigid superhydrophobic surfaces in a low-pressure environment are observed, and are due to a build-up of overpressure in the surface texture beneath the droplets.

Thomas M. Schutzius
Stefan Jung
Dimos Poulikakos
Research04 Nov 2015
Nature

Volume: 527, P: 82-85
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

Rejko Krüger
Wilfried Kuhn
Olaf Riess
Correspondence01 Feb 1998
Nature Genetics

Volume: 18, P: 106-108
Metabolic gatekeeper function of B-lymphoid transcription factors

The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensitizing acute lymphoblastic leukaemia B cells to glucocorticoid therapy.

Lai N. Chan
Zhengshan Chen
Markus Müschen
Research13 Feb 2017
Nature

Volume: 542, P: 479-483
Cross-species comparisons of cancer signaling

Modeling of human cancer in genetically engineered mice and genome-wide measurements of mRNA expression have now been combined to accelerate the search for new molecularly targeted therapies against cancer. Looking forward, we propose a community-wide systematic effort to model and characterize an array of different cancer-related aberrant signaling pathways in several mouse models of cancer.

Thomas G Graeber
Charles L Sawyers
News & Views01 Jan 2005
Nature Genetics

Volume: 37, P: 7-8
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

This study shows that, despite malignant transformation, autoimmune checkpoints are still functional in B-cell leukaemia, with targeted activation of these checkpoints effectively killing patient-derived B-cell leukaemia in a transplant model; the results represent a novel strategy to overcome drug resistance in leukaemia patients.

Zhengshan Chen
Seyedmehdi Shojaee
Markus Müschen
Research23 Mar 2015
Nature

Volume: 521, P: 357-361
A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation

A systems-wide study of mice infected with SARS-CoV2 under ketogenic diet shows that this diet reprograms the transcriptional and metabolic response in animals following infection with improved health, reduced inflammation, and restored metabolism.

Amelia Palermo
Shen Li
Arjun Deb
ResearchOpen Access03 Nov 2023
Communications Biology

Volume: 6, P: 1-15
BCL6 enables Ph⁺ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

Cihangir Duy
Christian Hurtz
Markus Müschen
Research18 May 2011
Nature

Volume: 473, P: 384-388
The cytoprotective aminothiol WR1065 activates p21^waf-1 and down regulates cell cycle progression through a p53-dependent pathway

S North
F El-Ghissassi
P Hainaut
Research07 Mar 2000
Oncogene

Volume: 19, P: 1206-1214
MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species

Elisabeth Roider
Alexandra I. T. Lakatos
David E. Fisher
ResearchOpen Access14 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours

C Scotton
D Milliken
F Balkwill
ResearchOpen Access11 Sept 2001
British Journal of Cancer

Volume: 85, P: 891-897
Ampk regulates IgD expression but not energy stress with B cell activation

Lynnea R. Waters
Fasih M. Ahsan
Michael A. Teitell
ResearchOpen Access03 Jun 2019
Scientific Reports

Volume: 9, P: 1-14
Gene expression in epithelial ovarian carcinoma

Daniela Matei
Thomas G Graeber
David D Chang
Research12 Sept 2002
Oncogene

Volume: 21, P: 6289-6298
Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy

Praveen K. Dhandapani
Isabel M. Begines-Moreno
Marten Szibor
ResearchOpen Access04 Sept 2019
Scientific Reports

Volume: 9, P: 1-13
Land-based salmon aquacultures change the quality and bacterial degradation of riverine dissolved organic matter

Norbert Kamjunke
Jorge Nimptsch
Norbert Hertkorn
ResearchOpen Access03 Mar 2017
Scientific Reports

Volume: 7, P: 1-15
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

Junhui Hu
Ping Tan
Lily Wu
ResearchOpen Access17 Apr 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-16
A linear mixed model approach to gene expression-tumor aneuploidy association studies

Douglas W. Yao
Nikolas G. Balanis
Thomas G. Graeber
ResearchOpen Access16 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
Targeting PEA3 transcription factors to mitigate small cell lung cancer progression

David W. Shia
WooSuk Choi
Brigitte N. Gomperts
ResearchOpen Access13 Dec 2022
Oncogene

Volume: 42, P: 434-448
Somatic copy number profiling from hepatocellular carcinoma circulating tumor cells

Colin M. Court
Shuang Hou
Vatche G. Agopian
ResearchOpen Access02 Jul 2020
npj Precision Oncology

Volume: 4, P: 1-9
Morphing and vectoring impacting droplets by means of wettability-engineered surfaces

Thomas M. Schutzius
Gustav Graeber
Constantine M. Megaridis
ResearchOpen Access13 Nov 2014
Scientific Reports

Volume: 4, P: 1-7
Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis

Nicolaos Jay Palaskas
Jacob David Garcia
Thomas Glen Graeber
ResearchOpen Access26 Nov 2019
Cell Discovery

Volume: 5, P: 1-10
CRAF R391W is a melanoma driver oncogene

Mohammad Atefi
Bjoern Titz
Thomas G. Graeber
ResearchOpen Access08 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma

Bjoern Titz
Anastasia Lomova
Thomas G Graeber
ResearchOpen Access06 Sept 2016
Cell Discovery

Volume: 2, P: 1-19

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