Nature Search

Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion

Histo-blood group antigens (HBGAs) have been proposed as essential cellular receptors for rotaviruses, which can cause severe diarrhoea in children. Here, the authors show that rotavirus strains display important variations in their ability to recognize different HBGAs.

Raphael Böhm
Fiona E. Fleming
Thomas Haselhorst
Research05 Jan 2015
Nature Communications

Volume: 6, P: 1-12
Sialic acid dependence in rotavirus host cell invasion

Thomas Haselhorst
Fiona E Fleming
Mark von Itzstein
Research21 Dec 2008
Nature Chemical Biology

Volume: 5, P: 91-93
Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease

The lysosomal storage disease mucopolysaccharidosis I is treated with recombinant α-L-iduronidase but production of the enzyme is expensive. In this study, α-L-iduronidase is compartmentalized within the endosperm of maize via a unique mRNA strategy yielding the active, correctly glycosylated protein.

Xu He
Thomas Haselhorst
Allison R. Kermode
Research18 Sept 2012
Nature Communications

Volume: 3, P: 1-9
Structure-guided discovery of potent and dual-acting human parainfluenza virus haemagglutinin–neuraminidase inhibitors

Human parainfluenza viruses (hPIVs) cause common respiratory diseases in children. Here the authors rationally design small molecules targeting the hPIV haemagglutinin–neuraminidase protein, and show that the compounds inhibit viral entry and exit from cultured cells.

Patrice Guillon
Larissa Dirr
Mark von Itzstein
Research20 Oct 2014
Nature Communications

Volume: 5, P: 1-11
Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

Ferrets constitute a useful model for influenza research because they are susceptible to human-adapted flu viruses. Here, the authors show that ferrets, like humans, lack a functional CMAH enzyme and synthesize a single type of sialic acid (Neu5Ac), resulting in naturally humanized influenza virus receptors.

Preston S.K. Ng
Raphael Böhm
Michael P. Jennings
ResearchOpen Access17 Dec 2014
Nature Communications

Volume: 5, P: 1-9
Functional and structural characterization of a heparanase

Structure and functional characterization of BpHep, a heparanase from the invasive pathogenic bacterium Burkholderia pseudomallei, defines its glycosaminoglycan recognition mechanism and its catalytic mechanism as an endo-acting glycoside hydrolase.

Lisa Bohlmann
Gregory D Tredwell
Mark von Itzstein
Research02 Nov 2015
Nature Chemical Biology

Volume: 11, P: 955-957
Unravelling the Role of O-glycans in Influenza A Virus Infection

Juliane Mayr
Kam Lau
Thomas Haselhorst
ResearchOpen Access06 Nov 2018
Scientific Reports

Volume: 8, P: 1-12
Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt’s lymphoma (BL) Daudi cells by NMR spectroscopy

Paul D. Madge
Andrea Maggioni
Thomas Haselhorst
ResearchOpen Access03 Nov 2016
Scientific Reports

Volume: 6, P: 1-12

Search

Filter By:

Search

Quick links