A second hit to Brca1 in heterozygous mice leads to accelerated tumor development compared to wild-type mice in which both alleles are simultaneously deleted. This is because of an epigenetic state associated with Brca1 haploinsufficiency that impacts AP-1 and Wnt10a.
- Carman Man-Chung Li
- Alyssa Cordes
- Joan S. Brugge
