Nature Search

Spermidine is essential for fasting-mediated autophagy and longevity

Hofer et al. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a conserved manner.

Sebastian J. Hofer
Ioanna Daskalaki
Frank Madeo
ResearchOpen Access08 Aug 2024
Nature Cell Biology

Volume: 26, P: 1571-1584
Patients with healed diabetic foot ulcer represent a cohort at highest risk for future fatal events

Julia K. Mader
Waltraud Haas
Harald Sourij
ResearchOpen Access17 Jul 2019
Scientific Reports

Volume: 9, P: 1-6
Cardioprotection and lifespan extension by the natural polyamine spermidine

Spermidine, a naturally occurring polyamine, extends the lifespan of mice and is cardioprotective in both aged mice and hypertensive rats. In humans, high dietary spermidine intake is associated with reduced blood pressure and a lower incidence of cardiovascular disease.

Tobias Eisenberg
Mahmoud Abdellatif
Frank Madeo
Research14 Nov 2016
Nature Medicine

Volume: 22, P: 1428-1438
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.

Didac Carmona-Gutierrez
Andreas Zimmermann
Frank Madeo
ResearchOpen Access19 Feb 2019
Nature Communications

Volume: 10, P: 1-17
A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery

Othmar Moser
Julia Münzker
Martin Ellmerer
ResearchOpen Access19 Jan 2018
Scientific Reports

Volume: 8, P: 1-8
Vitamin D status and arterial hypertension: a systematic review

In this extensive Review, Stefan Pilz and colleagues discuss the potential mechanisms by which vitamin D might affect blood pressure and explore the clinical evidence for an association between vitamin D and arterial hypertension. The authors also make recommendations for vitamin D supplementation in patients with hypertension and 25-hydroxyvitamin D levels below target values.

Stefan Pilz
Andreas Tomaschitz
Thomas R. Pieber
Reviews18 Aug 2009
Nature Reviews Cardiology

Volume: 6, P: 621-630
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

Polyamines such as spermidine and putrescine are known to promote autophagy and longevity in fruit flies. Similar to many other organisms, Drosophila also display age-induced memory impairment. Here, Gupta et al. find that a decrease in brain polyamines in aging Drosophila is correlated with age-dependent memory impairment. They also find that polyamines in flies' diet can alleviate this impairment, demonstrating a link between polyamines, autophagy and memory decline.

Varun K Gupta
Lisa Scheunemann
Stephan J Sigrist
Research01 Sept 2013
Nature Neuroscience

Volume: 16, P: 1453-1460
Aldosterone and arterial hypertension

Raised levels of aldosterone, but also concentrations within the normal range are associated with elevated blood pressure. The authors of this Review assess evidence for the role of aldosterone in the development and maintenance of hypertension, including experimental and clinical studies, and discuss the genetic and environmental mechanisms that underlie its effects.

Andreas Tomaschitz
Stefan Pilz
Thomas R. Pieber
Reviews22 Dec 2009
Nature Reviews Endocrinology

Volume: 6, P: 83-93
Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

Michaela Auer-Grumbach and colleagues report that missense alterations in the N-terminal ankyrin domain of TRPV4 underlie three distinct autosomal dominant disorders of the peripheral nervous system. Alterations in other regions of TRPV4 have been shown to underlie a family of autosomal dominant skeletal dysplasias, underscoring the marked clinical heterogeneity associated with mutations in this channel.

Michaela Auer-Grumbach
Andrea Olschewski
Christian Guelly
Research27 Dec 2009
Nature Genetics

Volume: 42, P: 160-164
The effect of spermidine on autoimmunity and beta cell function in NOD mice

Ceren Karacay
Barbara Prietl
Thomas R. Pieber
ResearchOpen Access16 Mar 2022
Scientific Reports

Volume: 12, P: 1-14
Author Correction: Systematic in vivo evaluation of the time-dependent inflammatory response to steel and Teflon insulin infusion catheters

Jasmin R. Hauzenberger
Julia Münzker
Thomas R. Pieber
Amendments and CorrectionsOpen Access11 Apr 2019
Scientific Reports

Volume: 9, P: 1
Systematic in vivo evaluation of the time-dependent inflammatory response to steel and Teflon insulin infusion catheters

Jasmin R. Hauzenberger
Julia Münzker
Thomas R. Pieber
ResearchOpen Access18 Jan 2018
Scientific Reports

Volume: 8, P: 1-9
Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors

Alfred A. Chan
Mina Bashir
Delphine J. Lee
ResearchOpen Access21 Jun 2016
Scientific Reports

Volume: 6, P: 1-11

Search

Spermidine is essential for fasting-mediated autophagy and longevity

Patients with healed diabetic foot ulcer represent a cohort at highest risk for future fatal events

Cardioprotection and lifespan extension by the natural polyamine spermidine

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery

Vitamin D status and arterial hypertension: a systematic review

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

Aldosterone and arterial hypertension

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

The effect of spermidine on autoimmunity and beta cell function in NOD mice

Author Correction: Systematic in vivo evaluation of the time-dependent inflammatory response to steel and Teflon insulin infusion catheters

Systematic in vivo evaluation of the time-dependent inflammatory response to steel and Teflon insulin infusion catheters

Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors

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