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Showing 1–6 of 6 results
Advanced filters: Author: Thomas Pradeu Clear advanced filters

  • Four leading tumour immunologists provide their opinions on the determinants of immunogenicity and how we might therapeutically improve tumour immunogenicity in the future.

    • Thomas Blankenstein
    • Pierre G. Coulie
    • Elizabeth M. Jaffee
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 307-313

  • Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms underlying the remarkable cancer resistance of some taxa. Therefore, this Perspective by Vincze et al. calls for the increased use of non-conventional model organisms in cancer research to advance cancer prevention and treatment strategies.

    • Orsolya Vincze
    • Benjamin Spada
    • Thomas Pradeu
    Reviews
    Nature Reviews Cancer
    Volume: 25, P: 740-748

  • The T helper subset paradigm has been instrumental in informing our understanding of T cell diversity; however, modern single-cell analyses have revealed the limits of the concept. In their Perspective, Becher and colleagues propose an alternative framework in which to understand T helper diversity, based not on transcription factors and cytokines but rather physiological functionality.

    • Selma Tuzlak
    • Anne S. Dejean
    • Burkhard Becher
    Reviews
    Nature Immunology
    Volume: 22, P: 1210-1217

  • Here, the authors present a new theoretical framework — the discontinuity theory — to account for how the immune system generates an appropriate immune response to any perceived disturbance. On the the basis of this theory, the authors present a mathematical model and provide examples to explain how this model can account for diverse immune responses.

    • Thomas Pradeu
    • Sébastien Jaeger
    • Eric Vivier
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 13, P: 764-769

  • Constitutive innate immune mechanisms, such as restriction factors, RNA interference, antimicrobial peptides, basal autophagy and proteasomal degradation, exert early host defence activities that also aim to minimize tissue damage and homeostatic disruption by limiting the activation of inducible innate immunity.

    • Søren R. Paludan
    • Thomas Pradeu
    • Trine H. Mogensen
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 137-150