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Showing 1–7 of 7 results
Advanced filters: Author: Thomas R. Gildea Clear advanced filters

  • Citizen science taps the efforts of non-experts. Here, authors describe Drugit, an extension of the crowdsourcing game Foldit, and its use in designing a non-peptide binder of Von Hippel Lindau E3 ligase for use with proteolysis targeting chimeras.

    • Thomas Scott
    • Christian Alan Paul Smethurst
    • Rocco Moretti
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • A machine learning model incorporating a wide range of administrative medical and demographic data from the US Army outperformed suicide risk screening questions in predicting suicide attempts over the 6 month period following soldiers’ annual medical examinations.

    • James A. Naifeh
    • Emily R. Edwards
    • Ronald C. Kessler
    Research
    Nature Mental Health
    Volume: 3, P: 242-252

  • Eberhardt et al. show that SARS-CoV-2 infects human coronary lesions where it preferentially targets plaque macrophages, triggering plaque inflammation and potentially leading to acute cardiovascular complications and long-term cardiovascular risks in patients with COVID-19.

    • Natalia Eberhardt
    • Maria Gabriela Noval
    • Chiara Giannarelli
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 899-916

    • Ernest S. Thomas
    News
    Nature
    Volume: 137, P: 213-215

  • BRAF mutations are frequent events in many different cancer types. Here, the authors highlight how distinct BRAF mutations affect the clonal dynamics and architecture of emergent tumours, with potential implications for therapeutic intervention.

    • Priyanka Gopal
    • Elif Irem Sarihan
    • Mohamed E. Abazeed
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Eller et al. develop a Facile Accelerated Specific Therapeutic (FAST) platform of antisense therapeutics that targets MDR bacterial pathogens with peptide nucleic acids (PNAs). This platform designs species and/or sequence specific PNAS based on a bioinformatics toolbox and offers a new delivery approach by repurposing the bacterial Type III secretion system in conjunction with a kill switch to overcome limited transport of PNAs into mammalian cells.

    • Kristen A. Eller
    • Thomas R. Aunins
    • Anushree Chatterjee
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13