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Showing 1–5 of 5 results
Advanced filters: Author: Thomas R. Weikl Clear advanced filters

  • The authors provide a litmus test for the recognition mechanism of transiently binding proteins based on nuclear magnetic resonance and find a conformational selection binding mechanism through concentration-dependent kinetics of ubiquitin and SH3.

    • Kalyan S. Chakrabarti
    • Simon Olsson
    • Christian Griesinger
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Many bacterial toxins and viruses deform membranes prior to entering cells via clathrin independent endocytosis. Here the authors show that multivalent lipid binding by globular particles can exceed a threshold adhesion energy required for membrane deformation and that this is sufficient for internalization.

    • Raluca Groza
    • Kita Valerie Schmidt
    • Helge Ewers
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • GPCRs include inactive and active states. 19F-NMR and stopped-flow fluorescence kinetic assays reveal that neurotensin activates the prototypical peptide-binding GPCR, neurotensin receptor 1, through an induced-fit mechanism, where ligand binding precedes receptor conformational changes.

    • Kazem Asadollahi
    • Sunnia Rajput
    • Paul R. Gooley
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Binding and unbinding kinetics are important determinants of protein-protein or small molecule protein functional interactions that can guide drug development. Here the authors exploit the multi-ensemble Markov model framework to develop a computational approach that allows the estimation of binding kinetics reaching into the seconds timescale.

    • Fabian Paul
    • Christoph Wehmeyer
    • Frank Noé
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10