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Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

Gary A. Koretzky
Joel Picus
Arthur. Weiss
Research05 Jul 1990
Nature

Volume: 346, P: 66-68
B cells inhibit induction of T cell-dependent tumor immunity

Zhihai Qin
Günther Richter
Thomas Blankenstein
Research01 May 1998
Nature Medicine

Volume: 4, P: 627-630
Enriching productive mutational paths accelerates enzyme evolution

By enriching productive mutational paths, a Kemp eliminase that speeds up proton abstraction >10⁸-fold was developed in only five evolution rounds. Recombining it with a variant differing by 29 substitutions revealed the underlying fitness landscape.

David Patsch
Thomas Schwander
Rebecca M. Buller
ResearchOpen Access11 Sept 2024
Nature Chemical Biology

Volume: 20, P: 1662-1669
Antarctic research

EDITH L. SMOOT
THOMAS N. TAYLOR
Correspondence01 Jan 1987
Nature

Volume: 325, P: 10
IL-12 protects from psoriasiform skin inflammation

IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue protective function of IL-12 in skin.

Paulina Kulig
Stephanie Musiol
Burkhard Becher
ResearchOpen Access28 Nov 2016
Nature Communications

Volume: 7, P: 1-14
Oxidation of interfacial cobalt controls the pH dependence of the oxygen evolution reaction

Transition metal oxides serve as important electrocatalysts for the oxygen evolution reaction, although Co-based oxides typically undergo pH-dependent dynamic surface reconstruction under catalytic conditions. Now the correlations between Co redox dynamics, flat band potential and Co oxidation state changes have been established to explain the pH dependency of oxygen evolution activity.

Jinzhen Huang
Adam H. Clark
Emiliana Fabbri
ResearchOpen Access28 Mar 2025
Nature Chemistry

Volume: 17, P: 856-864
Ultrafast small-scale soft electromagnetic robots

Inspired by fast running cheetahs, the authors present a class of small-scale soft electromagnetic robots able to reach ultra-high running speeds of 70 BL/s (body lengths per second) as well as the ability to swim, jump, steer and transport cargo.

Guoyong Mao
David Schiller
Martin Kaltenbrunner
ResearchOpen Access09 Aug 2022
Nature Communications

Volume: 13, P: 1-11
Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis

Biomarkers to indicate potential response to biologic therapeutics are needed for patients with psoriasis. Here the authors show that phosphorylation of NFκBp65 in cDC2 before therapy is an indication of non-response to the anti-TNF therapy adalimumab in patients with psoriasis.

Rosa Andres-Ejarque
Hira Bahadur Ale
Deborah Stocken
ResearchOpen Access06 Aug 2021
Nature Communications

Volume: 12, P: 1-16
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T_H17 cells

Korn and colleagues report that Sirpα⁺ dendritic cells trans-present the cytokine IL-6 to T cells through a process that requires its receptor IL-6Rα bound to dendritic cells and that trans-presentation is needed to generate pathogenic cells of the T_H17 subset of helper T cells in vivo.

Sylvia Heink
Nir Yogev
Thomas Korn
Research28 Nov 2016
Nature Immunology

Volume: 18, P: 74-85
A disease-associated gene desert directs macrophage inflammation through ETS2

ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.

C. T. Stankey
C. Bourges
J. C. Lee
ResearchOpen Access05 Jun 2024
Nature

Volume: 630, P: 447-456
Resilient yet entirely degradable gelatin-based biogels for soft robots and electronics

Stretchable and biodegradable elastic biogels based on gelatin, glucose, glycerol and citric acid are realized, whose mechanical properties can be adapted to a broad range of applications in soft robotics and wearable electronics.

Melanie Baumgartner
Florian Hartmann
Martin Kaltenbrunner
Research15 Jun 2020
Nature Materials

Volume: 19, P: 1102-1109
T cell regulation: a special job or everyone's responsibility?

Brigitta Stockinger
Thomas Barthlott
George Kassiotis
Correspondence01 Sept 2001
Nature Immunology

Volume: 2, P: 757-758
The Yin and Yang of type I interferon activity in bacterial infection

Thomas Decker
Mathias Müller
Silvia Stockinger
Reviews19 Aug 2005
Nature Reviews Immunology

Volume: 5, P: 675-687
Assessment of transcript reconstruction methods for RNA-seq

The RGASP consortium compared 25 RNA-seq analysis programs in their ability to identify exons, reconstruct transcripts and quantify expression levels. Assembly of isoforms and their expression levels in higher eukaryotes remains a challenge.

Tamara Steijger
Josep F Abril
Paul Bertone
ResearchOpen Access03 Nov 2013
Nature Methods

Volume: 10, P: 1177-1184
Neutralising SARS-CoV-2 RBD-specific antibodies persist for at least six months independently of symptoms in adults

Wagner et al. carry out a longitudinal seroepidemiological study of SARS-CoV-2 antibodies in a cohort of adults from a large company in Vienna, Austria. In individuals positive for S1-reactive antibodies at baseline, RBD-specific antibodies are most likely to persist for six months and correlate most closely with SARS-CoV-2 neutralizing ability.

Angelika Wagner
Angela Guzek
Ursula Wiedermann
ResearchOpen Access14 Jul 2021
Communications Medicine

Volume: 1, P: 1-11
Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery

Clarissa Schwab
David Berry
Tim Urich
ResearchOpen Access09 Jan 2014
The ISME Journal

Volume: 8, P: 1101-1114

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