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Showing 1–3 of 3 results
Advanced filters: Author: Thor S. Thorsen Clear advanced filters

  • Tetrahydrocannabinol (THC) analogs target the cannabinoid receptor CB1 for therapeutic and psychoactive effects. Here, the authors determine spatiotemporal ligand interactions critical for potency, efficacy, off-rates and drug design.

    • Thor S. Thorsen
    • Yashraj Kulkarni
    • David E. Gloriam
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • X-ray crystallography and molecular dynamics simulations of the μ-opioid receptor reveal the conformational changes in the extracellular and intracellular domains of this G-protein-coupled receptor that are associated with its activation.

    • Weijiao Huang
    • Aashish Manglik
    • Brian K. Kobilka
    Research
    Nature
    Volume: 524, P: 315-321