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Showing 1–2 of 2 results
Advanced filters: Author: Thorkell Gudjonsson Clear advanced filters
  • DNA damage arising from replication stress is well studied, but the effect of mitotic errors on genome integrity is less understood. Here the authors knock down 47 mitotic regulators and record how they impact on DNA breakage events, providing a resource for future studies on the relation between cell division and genome integrity.

    • Ronni S. Pedersen
    • Gopal Karemore
    • Claudia Lukas
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12
  • The early identification of patients with ulcerative colitis who have an increased risk of colorectal cancer would be useful for clinicians. In this Review, the authors discuss the most promising preneoplastic biomarkers, including p53 mutations, chromosomal instability and senescence, in ulcerative colitis. They also present the available knowledge regarding the pathogenesis of ulcerative colitis-associated colorectal cancer.

    • Sigrun Thorsteinsdottir
    • Thorkell Gudjonsson
    • Jakob Benedict Seidelin
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 8, P: 395-404