How membrane deformation and actin remodelling are coordinated to generate functional transport vesicles remains poorly understood. ARF1 coordinates clathrin coat recruitment and actin polymerization by binding the clathrin heavy chain binding protein, CYFIP, and facilitates Rac1-dependent actin polymerization to generate transport carriers at the trans-Golgi network.
- Mihaela Anitei
- Christoph Stange
- Bernard Hoflack
