Assembly of transcriptional repression complexes involves the recruitment of different proteins to SMRT or its homolog NCoR. Now structural and functional work reveal the tetrameric organization of the oligomerization domain of TBL1 and map its interactions with SMRT and GPS2. The authors propose a model for the architecture and assembly of the corepressor complex.
- Jasmeen Oberoi
- Louise Fairall
- John W R Schwabe
