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Showing 1–11 of 11 results
Advanced filters: Author: Thorsten Send Clear advanced filters

  • The role of the hippocampus in shaping dopaminergic prediction errors is unclear. Here, the authors show that without a functional hippocampus, dopaminergic neurons fail to properly encode prediction errors, particularly during changes in upper-level states.

    • Zhewei Zhang
    • Yuji K. Takahashi
    • Geoffrey Schoenbaum
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Generous behaviour increases happiness, but the neural underpinnings of this link are unknown. Here, authors show that promising to be generous changes the neural response in the temporo-parietal junction, and that the connection between this region and the ventral striatum was related to happiness.

    • Soyoung Q. Park
    • Thorsten Kahnt
    • Philippe N. Tobler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • The striatum contains two distinct types of GABAergic neurons, striatonigral and striatopallidal cells. Durieux and colleagues genetically ablated the striatopallidal population in mice, uncovering specific roles for these neurons in the control of locomotion and the response to the addictive drug amphetamine.

    • Pierre F Durieux
    • Bertrand Bearzatto
    • Alban de Kerchove d'Exaerde
    Research
    Nature Neuroscience
    Volume: 12, P: 393-395

  • High-throughput single particle cryo-EM, for instance in drug research, requires the automation of the single particle analysis workflow. Here, the authors present TranSPHIRE, a software package that allows the fully-automated, feedback-driven processing of cryo-EM datasets during data acquisition.

    • Markus Stabrin
    • Fabian Schoenfeld
    • Stefan Raunser
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Cancer patients exhibit specific sensitivities toward drug combinations that cannot be easily predicted. Here the authors setup a microfluidic platform that allows testing of multiple drug combinations correctly predicting sensitivity in vivo and they use it on patients biopsies to define effective drugs.

    • Federica Eduati
    • Ramesh Utharala
    • Christoph A. Merten
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Nerve damage can lead to skeletal muscle paralysis. The authors show that localized photostimulation of skeletal muscle expressing the light-sensitive channel Channelrhodopsin-2 generates contraction in the absence of neural impulses and prove that this strategy can be used for optogenetic opening of explanted murine vocal cords.

    • Tobias Bruegmann
    • Tobias van Bremen
    • Philipp Sasse
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Transient amnesic syndromes, such as transient global amnesia and transient epileptic amnesia, are often difficult to diagnose. Recent studies, however, have examined the structural and functional underpinnings of these disorders. In this Review, Bartsch and Butler discuss how these studies have improved our understanding of transient amnesic syndromes, summarizing the key clinical aspects of different amnesic disorders and providing recommendations for diagnosis and patient management.

    • Thorsten Bartsch
    • Christopher Butler
    Reviews
    Nature Reviews Neurology
    Volume: 9, P: 86-97