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Showing 1–6 of 6 results
Advanced filters: Author: Thorsten Trimbuch Clear advanced filters

  • Synaptic vesicle exocytosis is tightly regulated by a number of synaptic proteins, including complexin; however, several alternative models of complexin function have been presented. Trimbuch and Rosenmund propose that a better understanding of the properties of different domains of complexin may help to shed light on its function.

    • Thorsten Trimbuch
    • Christian Rosenmund
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 118-125

  • Ultrastructural analysis of synaptic vesicle recycling reveals that clathrin is not required for the initial rapid step of vesicle recycling by ultrafast endocytosis at the plasma membrane and instead clathrin acts later at an endosome to regenerate synaptic vesicles; however, when ultrafast endocytosis does not occur (for example, in experiments at room temperature rather than physiological temperature), clathrin-mediated endocytosis does happen at the plasma membrane.

    • Shigeki Watanabe
    • Thorsten Trimbuch
    • Erik M. Jorgensen
    Research
    Nature
    Volume: 515, P: 228-233

  • The interaction between RIM and the C2A domain of Munc13 is known to be required for synaptic vesicle priming. Here the authors show new implications of the C2A domain of Munc13, through its dynamic interaction with RIM, in orchestrating a wide range of modulatory operations that shape vesicle docking, priming and neurotransmitter release.

    • Marcial Camacho
    • Jayeeta Basu
    • Christian Rosenmund
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • In addition to their function in gene regulation, certain microRNAs can be secreted by cells. Here, the authors show that the microRNA let-7 can cause neurodegeneration by directly activating Toll-like receptor 7 and that individuals with Alzheimer's disease have more let-7b in their cerebrospinal fluid.

    • Sabrina M Lehmann
    • Christina Krüger
    • Seija Lehnardt
    Research
    Nature Neuroscience
    Volume: 15, P: 827-835