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Showing 1–8 of 8 results
Advanced filters: Author: Tiago C. Luis Clear advanced filters

  • The commitment stage at which progenitors seed the thymus remains unclear. Jacobsen and colleagues show that the earliest progenitors in the neonatal thymus have combined myeloid, T lymphocyte and B lymphocyte potential but not megakaryocyte-erythroid potential.

    • Sidinh Luc
    • Tiago C Luis
    • Sten Eirik W Jacobsen
    Research
    Nature Immunology
    Volume: 13, P: 412-419

  • The identity and lineage potential of the embryonic thymus-seeding progenitors that first seed the embryonic thymic rudiment is unclear. Jacobsen and colleagues find that these cells do not include multipotent stem cells or T cell–restricted progenitors but instead are lympho-myeloid progenitors.

    • Tiago C Luis
    • Sidinh Luc
    • Sten Eirik W Jacobsen
    Research
    Nature Immunology
    Volume: 17, P: 1424-1435

  • With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.

    • Amit Grover
    • Alejandra Sanjuan-Pla
    • Claus Nerlov
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • This Review covers the recently discovered roles of WNT proteins in the regulation of haematopoietic stem-cell fate, T- and B-cell development and activation, and dendritic-cell maturation. These new immunohaematological functions of WNT proteins have implications for the development of haematological malignancies.

    • Frank J. T. Staal
    • Tiago C. Luis
    • Machteld M. Tiemessen
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 581-593

  • Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

    • Joana Carrelha
    • Yiran Meng
    • Sten Eirik W. Jacobsen
    Research
    Nature
    Volume: 554, P: 106-111

  • The identification of a functionally distinct subset of haematopoietic stem cells (HSCs) that is primed for platelet-specific gene expression is described; the cells frequently have long-term myeloid lineage bias, can self-renew and give rise to lymphoid-biased HSCs, and may enable the design of therapies for enhancing platelet reconstitution.

    • Alejandra Sanjuan-Pla
    • Iain C. Macaulay
    • Sten Eirik W. Jacobsen
    Research
    Nature
    Volume: 502, P: 232-236