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In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Sand fly vector control strategies are limited. Here, Cecilio et al. use the bacteria Delftia tsuruhatensis TC1 to reduce the ability of sand flies to become infected with Leishmania parasites and effectively transmit them to mammalian hosts.

Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins.

Hematopoietic stem cells (HSCs) replenish blood cells. Here, Luis et al., identify a feedback mechanism by which IL-1 secreted by activated platelets signals through niche Lepr+ cells to activate HSCs and restore platelet homeostasis.

Mangroves store significant soil organic carbon, but the biogeochemical processes involved are not fully understood. This study reveals that poorly crystalline Fe oxides play a key role in stabilizing labile SOC in Amazonian mangroves, though land use change depletes this carbon pool.

The commitment stage at which progenitors seed the thymus remains unclear. Jacobsen and colleagues show that the earliest progenitors in the neonatal thymus have combined myeloid, T lymphocyte and B lymphocyte potential but not megakaryocyte-erythroid potential.

Covalent modification is an essential chemical method for altering the physicochemical properties of material interfaces. Here, the authors show that the no-slip conditions in microfluidic devices grant spatiotemporal control over molecular grafting.

Networks with higher-order interactions are relevant to variety of real-world applications, they can be good description of data even if the system has only pairwise interactions. The authors uncover the hypernetwork emergence in coupled nonlinear oscillators and electrochemical experiments.

The identity and lineage potential of the embryonic thymus-seeding progenitors that first seed the embryonic thymic rudiment is unclear. Jacobsen and colleagues find that these cells do not include multipotent stem cells or T cell–restricted progenitors but instead are lympho-myeloid progenitors.

Singlet fission is a promising carrier multiplication process, where a singlet exciton is split in two triplet states. Here the authors propose an oxygen-assisted two-step mechanism for singlet fission accounting for ~ 40% triplet quantum yield in dilute solutions where the single-step mechanism is inactive.

This Registered Report presents evidence from 87 countries and regions showing that brief emotion-regulation interventions consistently reduced negative emotions and increased positive emotions during the COVID-19 pandemic.

External physical forces can bias a spontaneous symmetry breaking process but whether the shape of a reactor plays a role in chiral symmetry breaking processes is an open question. Here, the authors demonstrate chirality transfer from the chiral shape of a 3D helical channel to chiral supramolecular aggregates whereby the handedness of the helical channel dictates the direction of enantioselection.

In this work, the authors identify Genipin as a small iridoid able to prevent alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.

Soils constructed from mine waste can help mitigate future mining-related carbon dioxide emissions by as much as 1 Gt CO₂eq in Brazil through supporting ecosystem carbon stock recovery, suggest estimates derived from geospatial analysis of legal mining activity and soil carbon in Brazil.

The biological understanding of poor prognosis associated with lymph node metastasis in head and neck cancer (HNC) remains crucial. Here, a proteomic characterisation of 140 multisite samples from a 59-HNC patient cohort and machine learning reveals potential biomarkers and metastasis related signatures.

Small molecules that inhibit α-synuclein misfolding may have potential in the treatment of Parkinson’s disease. Fonseca-Ornelas et al.show that several of these molecules fail to block misfolding in the presence of membrane vesicles, and reveal how phtalocyanine tetrasulfonate, in contrast, overcomes this effect.

Here, the authors use a double-reporter system to tag IFNγ-producing versus IL-17A-producing γδ T cells to compile a trancriptomic resource of these cell subsets in mice at steady state and in response to cerebral malaria or multiple sclerosis.

Human mutations in the NDE1 gene have been associated with cortical malformations and severe microcephaly. Here, the authors show in embryonic rat brains that NDE1-depleted neural progenitors arrest at three specific cell cycle stages before mitosis, resulting in a severe decrease in neurogenesis.

Haltalli et al. show that Plasmodium berghei infection induces interferon release, and affects haematopoietic stem cell proliferation and function, as well as osteoblasts and vascular integrity, in the bone marrow niche.

New treatments are essential for methicillin-susceptible Staphylococcus aureus bacteremia, but progress is slow. In this phase III–IV trial, cloxacillin plus fosfomycin failed to show superiority over cloxacillin alone, underscoring the challenges to improving patient outcomes.

With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.

Nerlov and colleagues show that expression of mKitL by cortical vascular endothelial cells is important for DN1 progenitor maintenance, whereas expression of mKitL by cortical thymic epithelial cells is required for maintaining DN2 progenitor cells.

Tir, a bacterial effector, exploits host-like disorder to rewire cellular processes via dimerization, lipid binding, and phosphorylation, revealing a versatile intracellular strategy for infection.

Including participants from 45 countries, Bago et al. find that the situational factors that affect moral reasoning are shared across countries, with diminished observed cultural variation.

The global impact of seabird populations on nutrient cycles is poorly understood. Here, the authors use a bioenergetic model and a global seabird population inventory to estimate the amounts of nitrogen and phosphorus excreted by seabirds and estimate them to be 591 Gg N y⁻¹ and 99 Gg P y⁻¹ respectively.

Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

The identification of a functionally distinct subset of haematopoietic stem cells (HSCs) that is primed for platelet-specific gene expression is described; the cells frequently have long-term myeloid lineage bias, can self-renew and give rise to lymphoid-biased HSCs, and may enable the design of therapies for enhancing platelet reconstitution.

This Review covers the recently discovered roles of WNT proteins in the regulation of haematopoietic stem-cell fate, T- and B-cell development and activation, and dendritic-cell maturation. These new immunohaematological functions of WNT proteins have implications for the development of haematological malignancies.

To evade autophagy-mediated killing when inside liver cells, the Plasmodium berghei protein UIS3 binds to a key regulator of the autophagy programme, the host protein LC3, and inhibits its interaction with downstream effectors.