Proton wires in enzyme active sites enable stereoselective reactions under mild conditions by facilitating dual activation of a nucleophile and an electrophile through reciprocal proton transfer. Now it has been shown that such an activation mode can be mimicked inside a supramolecular capsule, enabling a general approach to β-glycosides.
- Tian-Ren Li
- Fabian Huck
- Konrad Tiefenbacher
