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Author Correction: Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis

Lichan Tu
Ping Su
Wei Gao
Amendments and CorrectionsOpen Access15 Oct 2020
Nature Communications

Volume: 11, P: 1
Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease

Two-step Mendelian randomization, combined with multiple layers of omics evidence, implicates COL6A3-derived endotrophin as a mediator of coronary artery disease risk in the context of obesity.

Satoshi Yoshiji
Tianyuan Lu
J. Brent Richards
ResearchOpen Access24 Jan 2025
Nature Genetics

Volume: 57, P: 345-357
Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis

Using healthy mitochondria to restore impaired mitochondrial homeostasis is a promising therapy for pulmonary fibrosis. Here the authors use joint-engineered mesenchymal stem cells for efficient mitochondrial delivery to injured lung cells, showing a successful mitigation of the disease.

Ting Huang
Ruyi Lin
Jianqing Gao
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-15
Functional characterization of NES and GES responsible for the biosynthesis of (E)-nerolidol and (E,E)-geranyllinalool in Tripterygium wilfordii

Ping Su
Tianyuan Hu
Wei Gao
ResearchOpen Access27 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis

Tripterygium wilfordii is a medical plant that can produce antitumor activity compound triptolide. Here, the authors assemble its genome and identify a cytochrome P450 that can catalyze oxidation of a methyl to the acid moiety of dehydroabietic acid in triptolide biosynthesis by integrating multi-omics data.

Lichan Tu
Ping Su
Wei Gao
ResearchOpen Access20 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

Genome-wide association studies comprising 1,091 metabolites and 309 metabolite ratios in 8,299 individuals from the Canadian Longitudinal Study on Aging provide insights into the genetic architecture of metabolites and their role in human diseases.

Yiheng Chen
Tianyuan Lu
J. Brent Richards
Research12 Jan 2023
Nature Genetics

Volume: 55, P: 44-53
Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae

Hydroxylation at the C-14 position of triptolide is critical for its potent antitumor activity. Here, the authors report two CYP82Ds catalyze the 14-hydroxylation reaction via metabolic grid and achieve heterologous bioproduction of triptolide precursor in engineered Saccharomyces cerevisiae.

Yifeng Zhang
Jie Gao
Luqi Huang
ResearchOpen Access16 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

How obesity contributes to COVID-19 severity is not fully understood. In this study, Yoshiji et al. found that the plasma protein nephronectin partially mediates the effect of obesity on the risk of COVID-19 severity using a two-step Mendelian randomization approach and omics analyses.

Satoshi Yoshiji
Guillaume Butler-Laporte
J. Brent Richards
Research20 Feb 2023
Nature Metabolism

Volume: 5, P: 248-264
APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations

Yuheng Hong
Tianyuan Ren
Xianhuo Wang
Research14 Jul 2022
Leukemia

Volume: 36, P: 2269-2280
Implantable photonic neural probes with out-of-plane focusing grating emitters

Tianyuan Xue
Andrei Stalmashonak
Joyce K. S. Poon
ResearchOpen Access15 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
A CRISPR-Cas9 Assisted Non-Homologous End-Joining Strategy for One-step Engineering of Bacterial Genome

Tianyuan Su
Fapeng Liu
Qingsheng Qi
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-11
HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases

Use of UK Biobank whole-exome sequencing data to directly call HLA alleles is more accurate than imputing HLA alleles and reveals 360 associations for 11 auto-immune phenotypes, allow for better characterization of the role of the HLA region in human disease.

Guillaume Butler-Laporte
Joseph Farjoun
J. Brent Richards
ResearchOpen Access03 Nov 2023
Communications Biology

Volume: 6, P: 1-17
A synthetic population-level oscillator in non-microfluidic environments

A synthetic population-level oscillator in Escherichia coli is designed in non-microfluidic environments without the addition of inducers or frequent dilution.

Fei Gu
Wei Jiang
Quanfeng Liang
ResearchOpen Access13 May 2023
Communications Biology

Volume: 6, P: 1-12
Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma

Yiyi Xi
Yuan Lin
Dongxin Lin
ResearchOpen Access25 Feb 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Tunable switch mediated shikimate biosynthesis in an engineered non-auxotrophic Escherichia coli

Pengfei Gu
Tianyuan Su
Qingsheng Qi
ResearchOpen Access13 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
A rapid and reliable strategy for chromosomal integration of gene(s) with multiple copies

Pengfei Gu
Fan Yang
Qingsheng Qi
ResearchOpen Access08 Apr 2015
Scientific Reports

Volume: 5, P: 1-9

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Author Correction: Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis

Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease

Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis

Functional characterization of NES and GES responsible for the biosynthesis of (E)-nerolidol and (E,E)-geranyllinalool in Tripterygium wilfordii

Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae

Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity

APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations

Implantable photonic neural probes with out-of-plane focusing grating emitters

A CRISPR-Cas9 Assisted Non-Homologous End-Joining Strategy for One-step Engineering of Bacterial Genome

HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases

A synthetic population-level oscillator in non-microfluidic environments

Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma

Tunable switch mediated shikimate biosynthesis in an engineered non-auxotrophic Escherichia coli

A rapid and reliable strategy for chromosomal integration of gene(s) with multiple copies

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