Cells can sense and respond to their environment through mechanical forces. However, how the cell’s cytoskeleton transmits forces and how cytoskeletal proteins respond to forces is largely unknown. Now, a combination of mechanical perturbations and multiscale modelling offers insights into the molecular mechanisms behind the observed variations in the accumulation kinetics of the involved proteins in response to different types of deformation.
- Tianzhi Luo
- Krithika Mohan
- Douglas N. Robinson
