DNA double-strand breaks (DSBs) can affect many cellular processes, including transcription. Now the dynamics of RNA polymerase II is studied, following the induction of a single DSB within transcribed genes in human cell lines. The results reveal that the DSB causes inhibition of transcription elongation and reinitiation, in a manner that is dependent on the activity of DNA protein kinase and the proteasome.
- Tibor Pankotai
- Céline Bonhomme
- Evi Soutoglou
