Hsc70 disassembles the coats of clathrin-coated vesicles, remodels a number of other protein complexes, and facilitates protein folding. The dynamics of clathrin uncoating promoted by Hsc70 have now been monitored with single-particle fluorescence imaging. The results suggest that disassembly is driven by trapping of small conformational fluctuations.
- Till Böcking
- François Aguet
- Tomas Kirchhausen
