Nature Search

Structural basis of the allosteric behaviour of phosphofructokinase

Tilman Schirmer
Philip R. Evans
Research11 Jan 1990
Nature

Volume: 343, P: 140-145
X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

Gaston Pflügl
Jörg Kallen
Malcolm D. Walkinshaw
Research07 Jan 1993
Nature

Volume: 361, P: 91-94
Structural and mechanistic determinants of c-di-GMP signalling

c-di-GMP is a ubiquitous second messenger that is used by most bacteria to switch between a planktonic and a biofilm-related lifestyle. Here, Schirmer and Jenal review the most recent structural and functional data on GGDEF-, EAL- and PLZ domain-containing proteins, the key components of the c-di-GMP signalling network.

Tilman Schirmer
Urs Jenal
Reviews01 Oct 2009
Nature Reviews Microbiology

Volume: 7, P: 724-735
Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs

Bacterial multi-step phospho-relays employ receiver domains that act as intermediaries in phosphoryl shuttling. Here, the authors show that such a domain does not experience structural changes upon pseudo-phosphorylation, in contrast to the well-studied homologs in response regulators.

Mitchell Brüderlin
Raphael Böhm
Badri N. Dubey
ResearchOpen Access02 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase

As part of two-component systems, diguanylate cyclases (DGCs) are activated by phosphorylation. Structural and computational analyses of DgcR, a model DGC, reveal the phosphorylation-induced conformational changes and the activation mechanism likely shared by many DGCs with N-terminal coiled-coil linkers.

Raphael D. Teixeira
Fabian Holzschuh
Tilman Schirmer
ResearchOpen Access12 Apr 2021
Nature Communications

Volume: 12, P: 1-15
Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus

Crosstalk between small-molecule regulated networks controls growth in Caulobacter crescentus.

Viktoriya Shyp
Badri Nath Dubey
Urs Jenal
Research09 Nov 2020
Nature Microbiology

Volume: 6, P: 59-72
Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

Transcription factor binding to DNA is vital for gene regulation. Here, the authors determine the kinetics of DNA binding for RBPJ in living cells. They find that the binding is kinetically rather than thermodynamically stable evident from the effective binding energy landscape.

Duyen Huynh
Philipp Hoffmeister
J. Christof M. Gebhardt
ResearchOpen Access01 Feb 2025
Nature Communications

Volume: 16, P: 1-15
Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

FIC-domain-mediated adenylylation is controlled by inter- or intramolecular disturbance of the ATP binding site by an α-helix; such inhibition seems to be universal and conserved through evolution.

Philipp Engel
Arnaud Goepfert
Christoph Dehio
Research22 Jan 2012
Nature

Volume: 482, P: 107-110
Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter

Bacteria adapt their growth rate to their metabolic status and environmental conditions by modulating the length of their G1 period. Here the authors show that an increase in c-di-GMP concentration modulates the activity of kinase ShkA and transcription factor TacA, thus enabling G1/S transition in Caulobacter.

Andreas Kaczmarczyk
Antje M. Hempel
Urs Jenal
ResearchOpen Access10 Feb 2020
Nature Communications

Volume: 11, P: 1-16
NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL

Alena Sophie Ehrmann
Miguel Quijada-Álamo
Daniel Mertens
ResearchOpen Access02 Jun 2025
Leukemia

Volume: 39, P: 1892-1904
Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Badri Nath Dubey
Viktoriya Shyp
Tilman Schirmer
ResearchOpen Access21 Feb 2023
Scientific Reports

Volume: 13, P: 1-13

Search

Structural basis of the allosteric behaviour of phosphofructokinase

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

Structural and mechanistic determinants of c-di-GMP signalling

Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs

Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase

Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter

NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Search

Quick links

Search

Filter By:

Search

Quick links