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Showing 1–4 of 4 results
Advanced filters: Author: Tilo Grosser Clear advanced filters

  • This study identifies Prostaglandin E2 (PGE2) as an important modulator of vertebrate haematopoietic stem cell (HSC) number. Chemicals that enhance PGE2 synthesis increase the number of HSCs whereas the opposite effect is achieved by blocking PGE2 synthesis.

    • Trista E. North
    • Wolfram Goessling
    • Leonard I. Zon
    Research
    Nature
    Volume: 447, P: 1007-1011

  • Neutrophils are the first responders in acute inflammatory events such as acute respiratory distress syndrome and tend to home to lung capillaries during acute inflammation, where they can cause tissue damage by diapedesis and secretion of specific molecules. Here the authors show that nanoparticles coated with agglutinated proteins selectively target activated neutrophils in inflamed lungs and can be used for imaging and therapeutic purposes.

    • Jacob W. Myerson
    • Priyal N. Patel
    • Jacob S. Brenner
    Research
    Nature Nanotechnology
    Volume: 17, P: 86-97

  • Olga Troyanskaya and colleagues present genome-wide functional interaction networks for 144 human tissues and cell types. They identify important disease-gene associations by combining data from GWAS and tissue-specific networks. They also developed a webserver, GIANT, that includes multi-gene query capability, network visualization and analysis tools.

    • Casey S Greene
    • Arjun Krishnan
    • Olga G Troyanskaya
    Research
    Nature Genetics
    Volume: 47, P: 569-576