Nature Search

Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study

Surprisingly consistent replication failure of gray matter correlates of childhood maltreatment raises questions about publication bias in prior literature and about prevailing models linking maltreatment to brain structure in adult populations.

Janik Goltermann
Nils R. Winter
Udo Dannlowski
ResearchOpen Access16 Sept 2025
Nature Communications

Volume: 16, P: 1-14
Engineered heart muscle allografts for heart repair in primates and humans

Epicardial engineered heart muscle allografts from induced pluripotent stem cell-derived cardiomyocytes can safely and effectively remuscularize chronically failing hearts in rhesus macaques, leading to improved cardiac function and paving the way for human clinical trials.

Ahmad-Fawad Jebran
Tim Seidler
Wolfram-Hubertus Zimmermann
ResearchOpen Access29 Jan 2025
Nature

Volume: 639, P: 503-511
The murine T-cell receptor uses a limited repertoire of expressed V_β gene segments

Richard K. Barth
Byung S. Kim
Leroy Hood
Research01 Aug 1985
Nature

Volume: 316, P: 517-523
The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression

Kira Flinkenflügel
Marius Gruber
Udo Dannlowski
ResearchOpen Access01 May 2024
Molecular Psychiatry

Volume: 29, P: 3151-3159
Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Hypothalamic melanocortin neurons control energy homoeostasis by modulating appetite. Here, the authors reveal a role for the transcription factor Tbx3 as a regulator of the peptidergic identity and function of immature and mature mouse melanocortin neurons.

Carmelo Quarta
Alexandre Fisette
Matthias H. Tschöp
Research28 Jan 2019
Nature Metabolism

Volume: 1, P: 222-235
Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pencik
Michaela Schlederer
Lukas Kenner
Amendments and CorrectionsOpen Access26 Oct 2015
Nature Communications

Volume: 6, P: 1
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Consumption of high doses of the sweetener sucralose has immunomodulatory effects in mice, as a result of reduced T cell proliferation and differentiation.

Fabio Zani
Julianna Blagih
Karen H. Vousden
ResearchOpen Access15 Mar 2023
Nature

Volume: 615, P: 705-711
Trends and variability in the ocean carbon sink

Carbon uptake by the ocean has increased alongside rising atmospheric CO₂ concentrations, but with substantial variability. This Review examines trends in ocean CO₂ uptake and the internal and external factors driving its variability, finding an ocean uptake of –2.7 ± 0.3 Pg C year^–1 for the period 1990 through 2019.

Nicolas Gruber
Dorothee C. E. Bakker
Jens Daniel Müller
Reviews24 Jan 2023
Nature Reviews Earth & Environment

Volume: 4, P: 119-134
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states

Panzeri et al. use a Trim28^+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, linked to a relevant DNA hypomethylation signature.

Ilaria Panzeri
Luca Fagnocchi
John Andrew Pospisilik
ResearchOpen Access24 Jan 2025
Nature Cancer

Volume: 6, P: 385-403
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

The hypothalamic neuropeptide oxytocin exerts analgesic effects, but the underlying pathways remain largely elusive. Here, the authors describe an analgesic pathway formed by oxytocin neurons projecting to the periaqueductal grey, where axonally released oxytocin activates oxytocin-receptor expressing GABA neurons and subsequently reduces pain-like behaviors in both female and male rats.

Mai Iwasaki
Arthur Lefevre
Alexandre Charlet
ResearchOpen Access24 Feb 2023
Nature Communications

Volume: 14, P: 1-20
Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Liver resident CD8 T cells have an essential role in immunopathology in a mouse model of nonalcoholic steatohepatitis, by becoming auto-aggressive following sequential transcriptional and metabolic activation steps .

Michael Dudek
Dominik Pfister
Percy A. Knolle
Research24 Mar 2021
Nature

Volume: 592, P: 444-449
STAT3 regulated ARF expression suppresses prostate cancer metastasis

IL6-STAT3 signaling is activated in prostate cancer, however inhibiting this pathway has not lead to a survival advantage in patients. Here, Pencik et al.show that loss of the IL6-STAT3 axis in mice and humans leads to metastasis due to loss of ARF, unravelling STAT3 and ARF as potential prognostic markers in prostate cancer.

Jan Pencik
Michaela Schlederer
Lukas Kenner
ResearchOpen Access22 Jul 2015
Nature Communications

Volume: 6, P: 1-15
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling

Alexandra Winter
Marius Gruber
Udo Dannlowski
ResearchOpen Access15 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4613-4621
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Defective ribonucleotide excision repair causes ID4, an indel cancer signature characterized by deletions of 2–5 base pairs.

Martin A. M. Reijns
David A. Parry
Andrew P. Jackson
ResearchOpen Access09 Feb 2022
Nature

Volume: 602, P: 623-631
Oxygen minimum zone cryptic sulfur cycling sustained by offshore transport of key sulfur oxidizing bacteria

The presence and activity of sulfide-oxidizing denitrifying bacteria in sulfide-poor offshore oxygen minimum zone waters remains unclear. Here, the authors combine oceanography, molecular, biogeochemical and single-cell techniques to examine their distribution, metabolic capacity, and origins.

Cameron M. Callbeck
Gaute Lavik
Marcel M. M. Kuypers
ResearchOpen Access30 Apr 2018
Nature Communications

Volume: 9, P: 1-11
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice.

Christoffer Clemmensen
Sigrid Jall
Matthias H. Tschöp
ResearchOpen Access23 Oct 2018
Nature Communications

Volume: 9, P: 1-13
Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis

Anneke I den Hollander
Robert K Koenekoop
Ronald Roepman
Research03 Jun 2007
Nature Genetics

Volume: 39, P: 889-895
Correction: Global Impacts Dataset of Invasive Alien Species (GIDIAS)

Sven Bacher
Ellen Ryan-Colton
Tsungai A. Zengeya
Amendments and CorrectionsOpen Access08 Aug 2025
Scientific Data

Volume: 12, P: 1
Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

In male mice with diet-induced obesity, deletion of insulin inhibitory receptor (inceptor) in the whole body, in the brain and in pancreatic β cells improves glucose homeostasis, underlining a role of inceptor in regulating glucose homeostasis in the brain and pancreas.

Gerald Grandl
Gustav Collden
Timo D. Müller
ResearchOpen Access28 Feb 2024
Nature Metabolism

Volume: 6, P: 448-457
Author Correction: Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Michael Dudek
Dominik Pfister
Percy A. Knolle
Amendments and Corrections10 May 2021
Nature

Volume: 593, P: E14
Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Christoffer Clemmensen
Sigrid Jall
Matthias H. Tschöp
Amendments and CorrectionsOpen Access20 Nov 2018
Nature Communications

Volume: 9, P: 1
Independent phenotypic plasticity axes define distinct obesity sub-types

Yang et al. show that neuronatin (NNAT) can explain part of the phenotypic variation of complex traits, independently of genetics or the environment. Such NNAT-dependent variations can stratify human cohorts into four metabolic sub-types, including two distinct types of obesity.

Chih-Hsiang Yang
Luca Fagnocchi
J. Andrew Pospisilik
ResearchOpen Access12 Sept 2022
Nature Metabolism

Volume: 4, P: 1150-1165
Genetic, individual, and familial risk correlates of brain network controllability in major depressive disorder

Tim Hahn
Nils R. Winter
Jonathan Repple
ResearchOpen Access13 Jan 2023
Molecular Psychiatry

Volume: 28, P: 1057-1063
Publisher Correction: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Martin A. M. Reijns
David A. Parry
Andrew P. Jackson
Amendments and CorrectionsOpen Access03 May 2022
Nature

Volume: 605, P: E7
Astroglial clean-up of satiety synapses

Until now, the BDNF–TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.

Tim Gruber
Cristina García-Cáceres
News & Views02 May 2022
Nature Metabolism

Volume: 4, P: 505-506
An eclipsing substellar binary in a young triple system discovered by SPECULOOS

2M1510 is an approximately 45-million-year-old triple system of brown dwarfs, two of which form a close binary in a 20-day orbit and have almost the same mass (3.82% and 3.75% of the mass of the Sun, respectively). Their physical parameters are in good agreement with evolutionary models except for luminosity, suggesting that we might be underestimating the masses of brown dwarfs and massive exoplanets by about 30%.

Amaury H. M. J. Triaud
Adam J. Burgasser
Michaël Gillon
Research09 Mar 2020
Nature Astronomy

Volume: 4, P: 650-657
Advancing scientific knowledge in times of pandemics

This Comment article from the Precision Immunology Institute at the Icahn School of Medicine (PrIISM), New York, describes their efforts to provide critical reviews of COVID-19 articles posted daily on the preprint servers bioRxiv and medRxiv.

Nicolas Vabret
Robert Samstein
Uri Laserson
Comments & Opinion23 Apr 2020
Nature Reviews Immunology

Volume: 20, P: 338
Global Impacts Dataset of Invasive Alien Species (GIDIAS)

Sven Bacher
Ellen Ryan-Colton
Tsungai A. Zengeya
ResearchOpen Access21 May 2025
Scientific Data

Volume: 12, P: 1-10
Harmonizing government responses to the COVID-19 pandemic

Cindy Cheng
Luca Messerschmidt
Joan Barceló
ResearchOpen Access14 Feb 2024
Scientific Data

Volume: 11, P: 1-27
Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

Judith M. Boer
Maria Grazia Valsecchi
Rob Pieters
ResearchOpen Access01 Jul 2021
Leukemia

Volume: 35, P: 2978-2982
Association of brain white matter microstructure with cognitive performance in major depressive disorder and healthy controls: a diffusion-tensor imaging study

Susanne Meinert
Nico Nowack
Udo Dannlowski
ResearchOpen Access25 Oct 2021
Molecular Psychiatry

Volume: 27, P: 1103-1110
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Laura K. M. Han
Richard Dinga
Lianne Schmaal
ResearchOpen Access18 May 2020
Molecular Psychiatry

Volume: 26, P: 5124-5139
Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures

Eamonn Kennedy
Shashank Vadlamani
Giovana B. Zunta-Soares
ResearchOpen Access16 Oct 2024
Scientific Reports

Volume: 14, P: 1-15
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Advances in device-independent quantum key distribution

Víctor Zapatero
Tim van Leent
Marcos Curty
ReviewsOpen Access18 Feb 2023
npj Quantum Information

Volume: 9, P: 1-11

Search

Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study

Engineered heart muscle allografts for heart repair in primates and humans

The murine T-cell receptor uses a limited repertoire of expressed V_β gene segments

The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Trends and variability in the ocean carbon sink

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

STAT3 regulated ARF expression suppresses prostate cancer metastasis

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling

Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Oxygen minimum zone cryptic sulfur cycling sustained by offshore transport of key sulfur oxidizing bacteria

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis

Correction: Global Impacts Dataset of Invasive Alien Species (GIDIAS)

Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Author Correction: Auto-aggressive CXCR6⁺ CD8 T cells cause liver immune pathology in NASH

Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Independent phenotypic plasticity axes define distinct obesity sub-types

Genetic, individual, and familial risk correlates of brain network controllability in major depressive disorder

Publisher Correction: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

Astroglial clean-up of satiety synapses

An eclipsing substellar binary in a young triple system discovered by SPECULOOS

Advancing scientific knowledge in times of pandemics

Global Impacts Dataset of Invasive Alien Species (GIDIAS)

Harmonizing government responses to the COVID-19 pandemic

Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

Association of brain white matter microstructure with cognitive performance in major depressive disorder and healthy controls: a diffusion-tensor imaging study

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures

Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Advances in device-independent quantum key distribution

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