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Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Suzanne J. F. Kaptein
Olivia Goethals
Johan Neyts
Amendments and Corrections20 Oct 2021
Nature

Volume: 599, P: E2
Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

JNJ-1802—a highly potent dengue virus inhibitor—blocks the NS3–NS4B interaction within the viral replication complex, and is highly effective against viral infection with DENV-1 or DENV-2 in non-human primates.

Olivia Goethals
Suzanne J. F. Kaptein
Marnix Van Loock
ResearchOpen Access15 Mar 2023
Nature

Volume: 615, P: 678-686
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

The small molecule JNJ-A07 interferes with the interaction between the NS3 and NS4B proteins of dengue virus and reduces the viral load in mice even when first administered at peak viraemia.

Suzanne J. F. Kaptein
Olivia Goethals
Johan Neyts
Research06 Oct 2021
Nature

Volume: 598, P: 504-509
Molecular mechanism of respiratory syncytial virus fusion inhibitors

The binding of small-molecule inhibitors of the RSV F glycoprotein in a central cavity in the prefusion conformation stabilizes this conformation and blocks the conformational changes required for fusion with host membranes.

Michael B Battles
Johannes P Langedijk
Jason S McLellan
Research07 Dec 2015
Nature Chemical Biology

Volume: 12, P: 87-93
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Cryo-EM structure and inhibition assays reveal a non-nucleoside inhibitor of the respiratory syncytial virus polymerase complex that acts by binding to an induced-fit pocket in the capping domain.

Xiaodi Yu
Pravien Abeywickrema
Zhinan Jin
ResearchOpen Access21 Oct 2023
Communications Biology

Volume: 6, P: 1-12