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Advanced filters: Author: Tim Pollex Clear advanced filters

Enhancer–promoter interactions become more instructive in the transition from cell-fate specification to tissue differentiation

Analysis of enhancer–promoter (E–P) interactions during Drosophila embryogenesis suggests that the relationship between E–P proximity and activity depends on the developmental stage. Increased E–P proximity is associated with activity during differentiation but not specification.

Tim Pollex
Adam Rabinowitz
Eileen E. M. Furlong
ResearchOpen Access11 Mar 2024
Nature Genetics

Volume: 56, P: 686-696
Nuclear positioning and pairing of X-chromosome inactivation centers are not primary determinants during initiation of random X-inactivation

Relocalization of one X-inactivation center (Xic) to the nuclear lamina does not influence choice between the two Xics at the onset of X-chromosome inactivation. Tethering of both Xics to the nuclear lamina reduces Xic pairing but does not affect monoallelic Xist upregulation.

Tim Pollex
Edith Heard
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 285-295
DamC reveals principles of chromatin folding in vivo without crosslinking and ligation

A modified version of DamID allows measurement of chromosomal interactions without crosslinking and ligation, and provides validation for the existence of TADs in mESCs.

Josef Redolfi
Yinxiu Zhan
Luca Giorgetti
Research27 May 2019
Nature Structural & Molecular Biology

Volume: 26, P: 471-480

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