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Showing 1–5 of 5 results
Advanced filters: Author: Tim S Bugni Clear advanced filters
  • A combination of spectroscopy, metagenomics, and synthetic biology enables the characterization of the antiviral divamides, a class of lanthipeptide natural products in which even minor changes in structure lead to different biological activities.

    • Thomas E Smith
    • Christopher D Pond
    • Eric W Schmidt
    Research
    Nature Chemical Biology
    Volume: 14, P: 179-185
  • Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active against multidrug-resistant fungal pathogens.

    • Marc G. Chevrette
    • Caitlin M. Carlson
    • Cameron R. Currie
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11
  • Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.

    • Michelle A. Schorn
    • Stefan Verhoeven
    • Justin J. J. van der Hooft
    Comments & OpinionOpen Access
    Nature Chemical Biology
    Volume: 17, P: 363-368